PubMed Health⌕ Search

Biomedical subjects

C Halphen

Publications and source records attributed to C Halphen.

33 records · Page 2Linked to original sources
PubMed1978

Coronary artery disease in young women: clinical and angiographic features and correlation with risk factors.

Coronary arteriography was performed because of suspected coronary disease in 239 women less than 45 years of age. Normal coronary arteries were found in 112 women, and a further 23 had insignificant stenosis (less than 50 percent narrowing of luminal diameter). Of the remaining 104 women, 56 had one vessel, 22 two vessel and 26 three vessel disease. Hyperlipidemia, hypertension, diabetes, smoking and a family history of coronary disease were significantly more frequent in women with significant stenosis than in women with normal arteries. Significant coronary disease was found in 55 percent (100 of 182) of women with more than two risk factors but in only 7 percent (4 of 57) of those with less than two risk factors (P less than 0.0001). Evaluation of symptoms and the resting electrocardiogram also discriminated between women with and without coronary disease, but exercise testing was of little value. Only 4 of the 46 women with previous myocardial infarction had normal or near-normal coronary arteries. Among women with segmental wall motion abnormalities on ventriculography, the site was anterior in 90 percent (19 of 21) of women who used oral contraceptive drugs but in only 60 percent (21 of 35) of nonusers (P less than 0.05). However, in most respects, coronary artery disease in young women does not appear to differ from coronary disease in other patients.

Adult↗
PubMed1976

[Pitfalls of the normal electrocardiogram].

The authors report the cases of 7 patients with a normal basal electrocardiogram, whereas they were all affected with a high risk cardiovascular condition: coronary insufficiency in 3 cases, paroxysmal arrhythmia in 4 cases. They recall the limits of the conventional ECG and emphasise interest of dynamic recordings, with effort tests, and/on continuous ECG recording in the identification of certain transient heart manifestations.

Adams-Stokes Syndrome↗
PubMed1975

[Spontaneous angina with ST elevation. Significance and prognostic value].

The authors report 36 cases of spontaneous angina occurring in the absence (group A) or presence (group B) of a myocardial infarct (MI), either recent or old, and accompanied, during the attacks, by transient ST elevation (T ST E) and normal enzyme levels. Group A (16 cases) was characterised by : a) the severity of the prognosis with the development of rhythm disturbances during the attacks in 10 out of 16 cases, and of a MI and/or sudden death in 4 of the 6 cases treated medically; b) the presence, in 12 of the 14 cases explored of surgical stenosis of a major coronary trunck. The simple association of attacks of spontaneous angina and T ST E is in general sufficient to define severe angina, regardless of the height of the elevation, and for which a surgical indication (95 p. cent of our cases) with the same problems as those posed by Prinzmetal angina strictly defined on a series of clinical and electrocardiographic criteria. Group B (20 cases) :a) differed from group A by the incidence of cardiac failure (15 out of 20 cases), the widespread nature and degree of the anatomical lesions, not usually amenable to by-pass; b) the severe prognosis, reflected in 6 of the 17 cases treated medically by extension of the MI and/or sudden death, did not differ fundamentally from that of any subsequent relapse, regardless of its electrocardiographic signs. In these cases, the T ST E related to the presence of the MI does not have the same significance as in Prinzmetal angina, and progressive relapses of MI should no longer be classified in this group on the pretext that they are accompanied by T ST E.

Aged↗
PubMedDate not supplied

[Fulminant streptococcal gangrene of the lower limbs].

A 58 year old woman with Cushing's disease was admitted to hospital for acute ischaemia of the lower limbs due to fulminant streptococcal gangrene (necrosing fasciitis). A group A beta-haemolytic Streptococcus was isolated from the cutaneous lesions and the blood cultures. Despite antibiotic therapy and medical resuscitation, the patient died within 12 hours of her admission in a state of irreversible collapse. This gangrenous cellulitis, in which a hypersensitivity reaction plays a part in the pathophysiology, is a rare disease which is fatal in one half of cases. The diagnosis is based on a very marked alteration in the general state, the characteristics of the cutaneous lesions and, most importantly, the isolation of group A haemolytic Streptococci, which should be performed early so as to allow wide surgical excision, which remains the principal therapeutic measure, as rapidly as possible.

Cushing Syndrome↗