[Mechanism of induction of immunity to virus infections: interruption of intercellular virus multiplication].
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Adenoviridae Infections↗
Biomedical subjects
C Hamada
Publications and source records attributed to C Hamada.
[Immunofluorescent examination for adenovirus infection].
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Adenoviridae↗
Virus infection as a trigger of appendicitis: experimental investigation of Coxsackie B5 virus infection in monkey intestine.
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Animals↗
Serological analysis of some enzymes present in pseudorabies virus-infected and noninfected cells.
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Animals↗
Studies on poliovirus coproantibody. II. Characterization of neutralizing substance in fecal extracts.
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Adolescent↗
Pilot study of prescription-event monitoring in Japan comparing troglitazone with alternative oral hypoglycemics.
OBJECTIVE: To examine adverse events reported in a pilot study of the prescription-event monitoring in Japan (J-PEM) scheme, comparing troglitazone with other oral hypoglycemics. METHODS: We used a cohort study with a concurrent control in which information was gathered from both doctors and pharmacists. Crude event rates were calculated and compared between troglitazone (T) and alternative oral hypoglycemics (control drugs, C) using the likelihood ratio test. When the difference was statistically significant, possible confounding mechanisms were examined using Poisson regression analysis. RESULTS: Of 3,115 patient codes registered, pharmacists were sent 2,078 questionnaires and returned 1,814 (87%), while doctors were sent 1,858 questionnaires and returned 671 (36%). The difference in crude rates was statistically significant in 11 events (seven where T > C and four where C > T) reported by pharmacists and ten events (three where T > C and seven where C > T) reported by doctors. Among those, in two events, "weight increased" (T > C) and "abnormal hepatic function" (T > C), significant differences were observed in data from both doctors and pharmacists. Regression analysis revealed that the difference in crude rates for "nausea" (T > C) was possibly due to an uneven distribution of genders and that for "weight increased" (T >C) was possibly due to an uneven distribution of compliance. Patients with hepatic function abnormalities associated with troglitazone could be divided into two subtypes: one with a slight increase in serum lactate dehydrogenase concentration only and the other with elevated serum alanine aminotransferase. CONCLUSIONS: Comparison of the event rates between troglitazone and control drugs, followed by regression analysis, revealed several features of adverse events associated with drugs, including possible confounding mechanisms. Troglitazone-induced hepatic function abnormalities may be divided into two subtypes.
Adolescent↗
Effects of automated peritoneal dialysis on residual urinary volume.
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Automation↗
An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer.
To reappraise the benefits of the long supported chemotherapy with carmofur, a meta-analysis based on individual patient data from the three clinical trials was performed by pooling 614 patients from three trials, there is a statistically significant survival benefit (2p=0.032) and disease-free survival (DFS) benefit (2p=0.021) for carmofur; and a highly significant advantage for carmofur in DFS (2p=0.0004) and in survival (2p=0.004) in Dukes' C patients. This IPD meta-analysis strongly suggested an effect of oral carmofur in a long supported chemotherapy for curatively resected colorectal carcinoma.
Administration, Oral↗