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Biomedical subjects

C Hameed

Publications and source records attributed to C Hameed.

6 recordsLinked to original sources
PubMed1987

Lymphocyte subsets in the neonates of preeclamptic mothers.

With the aid of specific monoclonal antibodies, indirect immunofluorescence, and flow cytometry, peripheral blood lymphocyte populations were studied in 12 preeclamptic mothers and compared with those of ten normal patients at term. As well, lymphocyte subsets from newborns of these preeclamptic mothers and ten normal patients at term were studied. Lymphocytes were labelled with murine monoclonal antibodies directed against T cells and subsets of helper cells, suppressor/cytotoxic cells and natural killer cells. Cord blood lymphocytes of neonates from preeclamptic mothers showed a statistically significant reduction of total T cells, helper cells, and natural killer cells as compared to control. A significant reduction in helper/suppressor ratio was also observed. It is hypothesized that the differences in the immune system of the neonates in the preeclamptic group may be due to the stress of intrauterine malnutrition secondary to uteroplacental insufficiency.

Female↗
PubMed1987

Method and route of delivery in the low birth weight vertex presentation correlated with early periventricular/intraventricular hemorrhage.

Two hundred eighty patients with vertex presentation who were in spontaneous labor and delivered neonates weighing 2 kg or less were examined for early ultrasound evidence of periventricular/intraventricular hemorrhage. This was correlated retrospectively with delivery route (cesarean section versus vaginal delivery) and delivery method (low forceps delivery versus normal spontaneous delivery) in the group born vaginally. No correlation was evident between early periventricular/intraventricular hemorrhage and delivery route or method.

Apgar Score↗
PubMed1986

Correlation of fetal heart rate monitoring and acid-base status with periventricular/intraventricular hemorrhage in the low birthweight neonate.

We investigated the correlation of fetal heart rate patterns and fetal acid-base findings with the occurrence of early periventricular/intraventricular hemorrhage and variants. Ninety-five consecutive singleton neonates with birthweights less than or equal to 2000 gm were investigated. One-third of them showed early periventricular/intraventricular hemorrhage or variants. Fetal heart rate scores and umbilical arterial/venous acid-base status showed no correlation with results of scanning. The implications of these findings are discussed.

Acid-Base Equilibrium↗
PubMed1985

Lymphocyte subsets in women on low dose oral contraceptives.

Oral contraceptive users have been reported to have a higher incidence of viral, bacterial and fungal infections. This study was undertaken to try to elucidate some of the mechanisms responsible for this increased susceptibility to infection. Peripheral blood lymphocytes were labelled with murine monoclonal antibodies directed against T cells and the various lymphocyte subsets: helper cells, suppressor/cytotoxic cells, or natural killer cells. The lymphocytes were then analyzed on a Coulter Electronics Epics V fluorescent activated cell sorter (FACS). A total of 27 control and 33 oral contraceptive users were studied. In comparison to the control group, there was no significant difference between the two groups in percentage or absolute numbers of total T cells, helper cells, suppressor/cytotoxic cells or natural killer cells. This study suggests that the increase in herpes virus, C. trachomonas, candida, and other infections in women taking oral contraceptives is not related to alterations in the numbers of T lymphocyte subsets or in levels of NK cells.

Contraceptives, Oral↗
PubMed1984

Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy.

Thirty-seven consecutive patients with singleton pregnancies in "uncomplicated" preterm labor with intact membranes suitable for tocolysis were evaluated for evidence of silent chorioamnionitis by means of maternal serum C-reactive protein and amniotic fluid white blood cell count, Gram stain, and cultures. Abnormalities in these markers of infection were found to be significantly more common in cases that were refractory to tocolysis. These cases also showed both pathologic evidence of chorioamnionitis and a significantly greater neonatal early infectious morbidity. We conclude that silent chorioamnionitis is a significant cause of "uncomplicated" preterm labor refractory to conventional methods of tocolysis.

Amnion↗