PubMed Health⌕ Search

Biomedical subjects

C Haritoglou

Publications and source records attributed to C Haritoglou.

At least 19 recordsLinked to original sources
PubMed2006

[Long-term functional results after macular hole surgery. Results of a prospective study].

PURPOSE: This study reports on the long-term results of macular hole surgery with peeling of the ILM. METHODS: A total of 88 consecutive patients (71 female, 17 male, mean age 67 years) were prospectively evaluated. All patients underwent a standard pars plana vitrectomy with removal of the ILM and an intraocular gas tamponade. Preoperatively, as well as on each follow-up visit, a clinical examination including measurement of best corrected visual acuity, Goldman perimetry, and OCT was performed. RESULTS: The mean postoperative follow-up was 49 months; 83 (94%) patients were pseudophakic at the last examination. Anatomic closure was achieved in 84 (95%) patients. No late reopening of the macular hole was observed. Best corrected visual acuity improved in 82 patients (93%), remained unchanged in 2, and deteriorated in 4 patients. Best corrected visual acuity improved from a median of 0.2 preoperatively to a median of 0.6 postoperatively (p<0.001). Duration of symptoms as well as low preoperative visual acuity had no significant impact on anatomic and functional success. CONCLUSIONS: Macular hole surgery leads to good functional and anatomical results, even in the long term. A long history of visual impairment and low visual acuity before surgery are not contraindications to surgical intervention.

Aged↗
PubMed2006

[Staining techniques in macular surgery].

Over recent years, evolving surgical experience and the development of techniques in surgery for macular hole, macular pucker and other vitreoretinal diseases have improved anatomic and functional success rates. Today, there is common agreement by many surgeons that removal of the internal limiting membrane (ILM) is an effective and safe treatment option for conditions that involve the vitreoretinal interface.However, the ILM is a delicate and barely visible structure and its removal represents a challenge to the vitreoretinal surgeon. The introduction of vital dyes for ILM staining has led to better visibility of the ILM and epiretinal membranes, potentially making ILM peeling more controllable, easier and safer. It has opened the door, especially for the less experienced surgeon, to follow the principle of ILM removal in macular surgery. While the use of trypan blue and triamcinolone during such surgery seems to be safe, questions of the potential toxicity of indocyanine green (ICG) are currently being discussed. However, the underlying pathomechanisms are not yet completely understood. Whether the observations made on ICG-related toxicity will be sufficient to call ICG a "toxic adjunct" is currently under investigation. Further studies are required to better understand the safety margins of ICG and to investigate other vital dyes offering equal staining characteristics and a better safety profile.

Drug-Related Side Effects and Adverse Reactions↗
PubMed2006

[Susac syndrome: case reports and review of the literature].

BACKGROUND: Susac syndrome is a rare disease of unknown pathogenesis. It consists of retinal arterial occlusion, hearing loss and encephalopathy (triad). PATIENTS: The features of two cases of this syndrome are presented. CONCLUSION: A high percentage of patients do not have the clinical triad at the time of onset of symptoms and, therefore, this disease may be under-diagnosed. Any patient with unexplained encephalopathy should thus be examined by an ophthalmologist and have an audiogram performed.

Adult↗
PubMed2005

[Surgical treatment of cataract].

Today, the most frequently performed of all operative interventions is considered to be surgery for cataract. Modern surgical techniques applied under local anesthesia, tiny incisions that close spontaneously, reliable biometric methods, and the availability of artificial lenses, all combine to produce excellent results. In view of the low complication rate, this procedure can be recommended even in very old patients.

Aged↗
PubMed2005

[Circulatory disorders of the retina].

Cardiovascular diseases lead to systemic vascular regression, which, among other consequences, may result in an impairment of retinal perfusion. In view of the high level of comorbidity observed in patients with circulatory problems affecting the retina, the early recognition of mild forms of vascular retinopathy is of considerable importance. A major prerequisite for an improvement in outcome is the recognition of the fact that most circulatory disorders of the retina are due to systemic vascular disease, and the eye is an important prognostic indicator of cardiovascular morbidity and mortality. As a result, effective communication between family physician/internist and ophthalmologist is basic to the successful treatment of these diseases of the eye.

Anti-Inflammatory Agents↗
PubMed2005

[Age-related macular degeneration].

In the western world, macular degeneration is the most common cause of severe loss of vision and blindness in persons older than 50. The underlying cause of the condition is a disturbance in the interaction between the retina and choroid of the macula. Apart from age itself, genetic disposition and smoking are confirmed risk factors. In the initial stages, the patient experiences merely a mild blurring of vision. The wet form, which is usually progressive, is experienced as an acute loss of vision or distortion of the objects viewed. Underlying this wet macular degeneration is of new vessel growth from the choroid, known as choroidal neovascularization, which as a result of exudation of fluid and bleeding into the macula, destroys central vision. Apart from the administration of vitamins to slow down progression, laser coagulation, photodynamic treatment or vitreoretinal surgery may be helpful in some cases. A specific causal therapy is, however, not available.

Aged↗
PubMed2005

"Melanoma inhibitory activity" (MIA): a promising serological tumour marker in metastatic uveal melanoma.

PURPOSE: To assess the role of "melanoma inhibitory activity" (MIA) as a potential serum marker for screening and detection of metastatic uveal melanoma. DESIGN: Prospective, clinical study. MATERIAL AND METHODS: Serum samples of 305 patients with uveal melanoma were collected. Serum samples were analysed by a one-step enzyme-linked immunosorbent assay (ELISA) to quantify the MIA serum levels. All patients underwent a standardized echography of the globe to evaluate maximum tumour height and were checked for systemic metastasis of the tumour by liver enzyme tests and ultrasonography of the liver. RESULTS: Twenty patients (6.6%) had proven metastatic disease; eight of them developed it during follow-up. The mean serum concentration of MIA in the 285 patients without metastasis was 6.72 ng/ml, whereas the mean serum concentration of MIA in the 20 patients with metastasis was 13.03 ng/ml (P<0.001). The eight patients who developed metastatic disease during follow-up showed an MIA of 5.92 ng/ml before detection of metastasis and 12.21 ng/ml afterwards (P<0.001). MIA serum levels did neither correlate with the tumour height or to whether local therapy had been applied. CONCLUSION: The elevation of MIA serum levels in patients with metastatic disease from melanoma supports its promising role as a serum marker for monitoring patients with uveal melanoma.

Adult↗
PubMed2005

[Bilateral lid swelling during infectious mononucleosis (Hoagland-sign)].

BACKGROUND: Infectious mononucleosis ("kissing disease") is an infection caused by Epstein-Barr-Virus (EBV, human herpes virus 4). METHODS: We present the case of an 18-year old female patient with dacryoadenitis and sub-febrile temperatures followed by a distinct feeling of sickness. RESULTS: Laboratory results revealed a Leukocytosis of 16.3 G/I with explicit elevation of hepatic parameters. The ultrasound scan of the orbital region showed a bilateral, echo-reduced, compressible lesion in the area of the lachrymal gland. The abdomen-ultrasound scan revealed a splenomegaly and the size of the liver was within normal limits. Serology was positive for EBV-VCA-IgG, EBV-EA-IgG and EBV-VCA-IgM. CONCLUSIONS: A dacryoadenitis can be the presenting symptom of an infectious mononucleosis.

Adolescent↗
PubMed2005

Full thickness eyelid transsection (blepharotomy) for upper eyelid lengthening in lid retraction associated with Graves' disease.

AIM: To report on a modified technique for upper eyelid lengthening in lid retraction associated with Graves' disease. METHODS: A prospective consecutive interventional case series. 41 patients, 38 women and three men, with a mean age of 55 years (range 32-75 years) were included. Full transsection of the upper eyelid with optional transsection of the lateral horn was performed in 60 lids. A central bridge of conjunctiva was left intact in the pupillary axis. Before and after surgery, the skin crease, palpebral aperture, and scleral show were measured and the contour of the lid margin was assessed. The overall result was graded as "perfect," "acceptable," and "failure." RESULTS: The mean period review was 6 months (range 2-36 months). Preoperatively, upper eyelid retraction varied from 1 mm to 7 mm; mean scleral show was 2 mm in 45 lids, the palpebral aperture was in the desired height (SD 1 mm) in 53 of 60 lids (88%) and was reduced by 3 mm (mean), the skin crease remained unchanged (SD 1 mm) in 44 of 60 lids (73%). The result was considered "perfect" in 43 and "acceptable" in 14 of 60 lids after one or two surgical approaches. In three lids, the surgery had failed. CONCLUSION: In contrast with other surgical techniques the surgical approach presented here is easy to perform and still leads to very satisfying and predictable postoperative results.

Adult↗
PubMed2004

Retinal vascular abnormalities in CADASIL.

To assess retinal vascular alterations in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the authors examined 10 affected individuals with ophthalmologic evaluation including fluorescence angiography. Findings included bilateral peripapillary arteriolar sheathing (30%), arteriolar narrowing (80%), and arteriovenous nicking (90%). No retinal infarcts, vascular occlusions, exudation, or hypoperfusion of affected vessels were found.

Adult↗
PubMed2004

[Clinical and genetic results with reference to corneal alterations in Lowe-syndrome].

BACKGROUND: The Lowe oculo-cerebro-renal syndrome (OCRL1) is a rare X-linked disease which causes impairment of visual acuity. The situation may be further complicated by corneal alterations. PATIENTS AND METHODS: In total seven patients from different families were clinically examined by slit-lamp examination, funduscopy, measurement of the intraocular pressure and ultrasound sonography. Molecular genetic analysis was performed in six patients by sequencing large PCR amplicons with a DNA sequencer and the ABI PRISM Sequence navigator software. RESULT: All affected boys were aphakic. Due to high intraocular pressure, iridectomy, goniotomy, cyclo-cryo treatment or trabeculectomy were performed. All patients showed opacity or pannus-like alterations of the cornea. Molecular genetic analysis revealed four novel and two known mutations. CONCLUSION: Reduced visual acuity was partly explained by morphological changes due to the underlying genetic defect and the development of cataract and glaucoma. Opacity of the cornea as well as alterations of the cornea seem to be a major problem in the course of the disease.

Adult↗
PubMed2004

[Surgery for macular edema].

At the end of the nineteenth century, "macular edema" had already been recognized as a pathological condition. The main causes for macular edema are vascular, inflammatory, degenerative, and congenital diseases or trauma. The therapeutic approaches have changed along with the increasing knowledge on the underlying causes of action during the last few years and include laser treatment as well as surgical interventions. Pars plana vitrectomy (including ILM peeling) seems beneficial in cases of macular edema that are associated with alterations of the vitreous or the vitreoretinal interface. For the treatment of chronic macular edema, intravitreal application of agents such as triamcinolone has become an option.

Anti-Inflammatory Agents↗
PubMed2003

[Regression of an uveal metastatic tumor from breast cancer during chemotherapy--a case report].

BACKGROUND: Choroidal metastases generally respond well to radiation treatment. However, a deterioration of visual acuity after radiation must be taken into account in lesions involving the optic nerve. In these cases, alternatives to radiation, which is a palliative treatment in most cases anyway, should be considered. MATERIAL AND METHODS: We present the clinical and echographic findings of a case of a 39-year-old patient with choroidal metastasis from breast carcinoma. RESULTS: We observed a regression of the metastasis and an improvement of visual acuity from 0.2 to 1.0 under systemic chemotherapy. Echography showed a decrease of tumor height and increasing reflectivity indicating progressive scarring of the lesion. Up to now, the patient has survived 9 years after initial diagnosis. CONCLUSIONS: Especially in cases in which a deterioration of visual acuity after radiation must be expected, the follow-up during systemic chemotherapy alone might be considered an alternative option, as it not only might preserve vision, but also allows an "in vivo" monitoring of the success of the chemotherapy applied.

Adult↗