Lipids in British schoolchildren.
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Adolescent↗
Biomedical subjects
C Harwood
Publications and source records attributed to C Harwood.
Dystrophin in skeletal muscle. I. Western blot analysis using a monoclonal antibody.
The value of analysing dystrophin on Western blots of skeletal muscle for the differential diagnosis of Xp21 muscular dystrophies is now fairly well established. Here we describe a sensitive system based on monoclonal antibodies to dystrophin. The specificity of the antibodies was established and experiments were undertaken to identify the source of dystrophin-related protein bands which were detected on blots of normal skeletal muscle. These investigations formed a necessary preliminary study to the application of the assay to samples of muscle obtained at biopsy from patients with Duchenne and Becker muscular dystrophy.
Antibodies, Monoclonal↗
A compact computer printer for quality control spirometric data collection.
A new microcomputer, the Datamite III, was tested with a standardized group of known physiologic spirometric inputs. These test inputs were developed by the National Institute for Occupational Safety and Health, and are recommended by the Association for Advancement of Medical Instruments. They exhibit a wide range of flows and volumes along with initial and terminal hesitation in order to test, under the most severe conditions, all aspects of automated data collection, such as initiation and termination thresholds, sampling rate, back extrapolation logic and data reduction. For all measured spirometric parameters, the accuracy of the Datamite III in computing data from these curves was well within all published requirements. Correlation coefficients of 1.000 were obtained between computed and delivered values for forced expiratory volume at 1s (FEV1), forced vital capacity (FVC), FEV1/FVC, and forced expiratory flow between 25% and 75% of the FVC (FEF25-75). In addition, the Datamite III provides maximum technician support for enhanced quality control through unique program features.
Computers↗