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Biomedical subjects

C Heard

Publications and source records attributed to C Heard.

3 recordsLinked to original sources
PubMed1992

"Primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human CD4.

Immunoglobulin variable region genes from non-human primates, cynomolgus macaques, were shown to have 85%-98% homology with human immunoglobulin sequences and yet macaques are phylogenetically distant enough to respond against conserved human antigens. Immunoglobulin genes were isolated from monkeys immunized with human CD4 antigen and a human/monkey chimeric anti-CD4 antibody with 91-92% homology to human immunoglobulin framework regions was cloned and expressed. The antibody has an apparent affinity of 3.2 x 10(-11) M and exhibits potent immunosuppressive properties in vitro.

Animals↗
PubMed1977

Occupational role acquisition: a perspective on the chronically disabled.

Occupational therapists are aware that chronic disability restricts not only physical and mental skills, but also social skills and the resulting ability of the patient to function in society. The issue of quality of life for the chronically disabled requires assisting them in the acquisition of new, although not always remunerative, occupational roles. The occupational role defines daily activity and appropriation of time, as well as the contribution to society and societal worth. This article presents the sociological concepts of role, three critical points in conceptualization of the occupational role acquisition process, a model for evaluating and monitoring a patient's progress, and a case study.

Adolescent↗