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C Hedberg

Publications and source records attributed to C Hedberg.

14 recordsLinked to original sources
PubMed2003

The TNF-alpha -308, MCP-1 -2518 and TGF-beta1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants.

Chronic lung disease (CLD) in premature newborns is associated with increased concentrations of inflammatory cytokines in tracheal aspirates (TA). We determined if polymorphisms of cytokine genes influence the risk of developing CLD by genotyping 178 mechanically ventilated very low birth weight (VLBW) infants for the tumor necrosis factor-alpha (TNF-alpha) -308 G/A, transforming growth factor-beta(1) (TGF-beta(1)) +915 G/C and monocyte chemoattractant protein-1 (MCP-1) -2518 A/G polymorphisms. Genomic DNA was isolated from TA and genotypes determined by restriction length polymorphism. There was no effect of any of these polymorphisms on the development of CLD (29 vs 23%, P=0.371, TNF-alpha -308 AA/AG vs TNF-alpha -308 GG; 23 vs 26%, P=0.681, MCP-1 -2518 GG/AG vs MCP-1 -215-8 AA; 24 vs 24%, P=0.978, TGF-beta(1) +915 CG vs TGF-beta(1) +915 GG). TA IL-8 and MCP-1 concentrations were not different between genotype groups. Infants with the TNF-alpha -308 A allele had increased risk of IVH (RR 2.07; 95% CI 1.02-4.18, P=0.041) and infants with the TGF-beta(1) +915 C allele were at greater risk of death (32 vs 9%, P=0.016). These data suggest that these polymorphisms do not play a significant role in determining risk for CLD in preterm infants, but may play a role in other complications in the neonatal period.

Case-Control Studies↗
PubMed1999

Food-borne disease in the 21st century. What challenges await us?

As the world shrinks and international commerce expands, food-borne illness is likely to become a major public health focus worldwide. Improved surveillance, community education, thorough understanding of the food production chain, use of HACCP strategies, and ionizing radiation are all important for reducing the risks. Primary care physicians play a crucial role in surveillance and early reporting, as well as in educating the public on the importance of basic food safety.

Foodborne Diseases↗
PubMed1992

[Body and existence].

The intention of this article is to introduce a complement to the natural science paradigm by giving medicine, especially general practice, a dimension of understanding inspired by existential philosophy. The presuppositions of natural science regarding human nature dividing body and soul, subject and object, are discussed and found insufficient for an understanding of what it means to be human. Case studies illustrate that for the patient, the meaning of symptom in existential terms has vast practical consequences for deciding treatment.

Body Image↗