A sample size program for "proving the null hypothesis".
A flexible APL computer program is presented for assistance in planning clinical trials designed to test the equivalence of two therapies. It is a substitute for the sample size graphs of Blackwelder and Chang and provides the option to calculate any of the six characteristics--sample size, significance level, power, success probability of standard therapy, success probability of experimental therapy, and minimum difference of interest--if five of them are prespecified.
Clinical Trials as Topic↗