Penicillin epilepsy in isolated islands of hippocampus.
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Biomedical subjects
Publications and source records attributed to C Herman.
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Long-term potentiation was studied in vivo in the rat barrel cortex. It was found that LTP lasting several hours could be induced in layer II/III by tetanic stimuli applied in layer IV. The probability of inducing LTP at a given site was high (86%) provided that the electrodes were not displaced too far horizontally. LTP was not observed if the stimulating electrode was located on the far side of the neighbouring barrel-column from the recording electrode. The strongest LTP was induced by stimulating layer IV septal locations or the edge of the barrel and recording in the near half of the neighbouring barrel. However, examples were found of LTP from layer IV to II/III within the same barrel, within the same septum and from barrel to adjacent septum. The probability of inducing LTP on a particular occasion was greatly increased by iontophoresis of bicuculline at the recording site during the tetanus (from 20 to 55% judged by a change in peak amplitude). The average increase in the peak amplitude was 29 +/- 3.2% for protocol 1 (urethane anesthesia, monopolar stimulation) and 23 +/- 7% for protocol 2 (barbiturate anesthesia, bipolar stimulation). The probability of inducing LTP was greater if the first tetanus was accompanied by BMI application (67%) than for any subsequent attempts (39%). These results suggest it should be possible to study the effect of LTP on sensory processing in defined positions within the barrel field.
Have death personifications changed over the past quarter of a century? A 1971 study explored the death personifications of college students, student nurses, nurses, and mortuary science students. The present study focused on 123 students of nursing and 324 students enrolled in general study courses at a large university in the American Southwest. The study also explored the possibility that Dr. Jack Kevorkian may have emerged as a contemporary image of death. Respondents were asked to imagine death as a character in the movies and to indicate the nature of this character through fixed-choice alternatives. Respondents were also asked to identify the sources or models for their personifications of death. It was found that male personifications of death still predominate, but that female personifications occur with greater frequency than in the earlier study, especially among female respondents. Although the "Gentle Comforter" is most often seen as an elderly person, overall the relationship between age and death personification appears to have weakened. There is now a larger divergence between the sexes in type of death personification selected most frequently. Females most often select "kind and gentle" imagery; males now are more likely to see death as a "cold, remote" person. Grim and terrifying images of death occur with some frequency, but are the least often selected by respondents of either sex. There was no evidence to support the emergence of a Kevorkian-type death personification, although he was identified correctly by almost all respondents and was viewed favorably by a majority.
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