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Biomedical subjects

C Hicks

Publications and source records attributed to C Hicks.

At least 91 records · Page 5Linked to original sources
PubMed1991

Linkworkers in antenatal care: facilitators of equal opportunities in health provision or salves for the management conscience?

A number of reports have highlighted non-English speaking Asian women as being at risk from limited health care provision (eg Whitehead, 1987). Of particular relevance to the present survey is their low uptake of antenatal care which may contribute to the above-average perinatal mortality rates for this group. In an attempt to ameliorate this problem, a Linkworker service was introduced in a number of multi-racial health districts. The survey reported here was an attempt to establish the efficacy of this service. From an initial sample of 30 health districts, 20 replies were obtained which provided some valuable insights on the current status of the Linkworker provision. In summary, the responses indicated that there is a worrying mis-match between client need and service planning, largely because relevant information about supply and demand is not collated. The net result is that many of the at-risk group are still denied the full and appropriate services of the Linkworker. It is concluded that if Linkworker provision is seen as a valuable commodity in enhancing equal opportunities in health care, then the service needs to be systematised. If it is perceived to be of little demonstrable value, then it should be scrapped. In either case, some clear policy decisions are required.

Asia↗
PubMed1991

Investigation of interleukin 2 receptors on human endothelial cells.

We have demonstrated that both recombinant and purified IL-2 exert a direct effect on quiescent human microvascular endothelial cells in vitro, causing the cells to enter the cell cycle and proliferate (Hicks et al., 1989). In this study we have identified IL-2 receptors (R) on both human umbilical vein (HUVEC) and neonatal foreskin (HCEC) endothelial cells. The techniques used to identify the receptors included proliferation studies, flow cytometry and immunofluorescence. Results indicate that both HUVEC and HCEC possess low numbers of receptors since both cell types proliferate in response to IL-2. The number of receptors on the cell surface vary according to passage number and culture conditions. Immunofluorescent studies show discrete areas of staining on the cell membrane. These combined results suggest that human vascular endothelial cells possess IL-2R.

Cell Division↗
PubMed1990

Monoclonal antibodies and arthritis.

Monoclonal antibodies to certain cell surface constituents on lymphocytes, monocytes and macrophages have been administered to Lewis rats with developing, established or adoptively transferred arthritis, to determine any immunomodulatory properties. Anti-CD4 antibodies against helper T-lymphocytes produced a dose related inhibition of developing arthritis; high dose levels completely suppressed all symptoms of arthritis and these rats were resistant to further attempts to induce arthritis. Anti-Ia (MHCII) antibodies also inhibited arthritis in a dose related manner; anti-pan T antibodies delayed the onset of arthritis, but antibodies against CD8 and IL-2 receptor positive cells were without effect. Development of type II collagen-induced arthritis was also inhibited by anti-CD4 treatment. Established arthritis could be temporarily inhibited by anti-CD4 antibodies, but rebound of arthritis invariably occurred after stopping treatment, as is the case with cyclosporin A. Similar results with anti-CD4 antibodies were obtained during treatment of arthritis adoptively transferred by arthritogenic T-lymphocytes. From these experiments it is clear that CD4 positive T-lymphocytes have a major role in the induction of adjuvant arthritis and that interaction between CD4 and Ia bearing cells is important. The rebound of arthritis that occurred after withdrawal of anti-CD4 treatment during established disease infers that cells in addition to helper T-lymphocytes are involved in the chronicity of arthritis, but these remain to be elucidated. These findings are discussed in relation to results with monoclonal antibodies in other models of arthritis and human rheumatoid arthritis; the prospects for human therapy are also discussed.

Animals↗
PubMed1989

Response of microvascular endothelial cells to biological response modifiers.

This study investigated in vitro biological response modifiers (BRM) possibly involved in initiation and regulation of human capillary endothelial cell (HCEC) growth. An indicator assay was developed using tritiated thymidine to measure increased DNA turnover. Purified or recombinant BRMs tested singly and in combination included: interferon (IFN; alpha and gamma), tumour necrosis factor (TNF; alpha and beta), transforming growth factor (TGF; alpha and beta), rIL-1, rIL-2, pIL-2, platelet derived growth factor (PDGF) and retinoic acid. Under limiting serum conditions only rIL-2 (greater than or equal to 10 U/mL) caused proliferation of the cells. gamma IFN together with TNF alpha(500 U/mL of each) was cytotoxic. Under maximal stimulus conditions, a cytostatic effect resulted from exposing HCEC to: alpha or gamma IFN (greater than or equal to 1000 U/mL), TGF beta (greater than or equal to 5 ng/mL), rIL-1 (greater than or equal to 0.5 U/mL) and rIL-1 plus gamma IFN. gamma IFN (500 U/mL) plus TNF alpha exhibited synergism in the inhibition of proliferation and produced a cytotoxic effect at TNF alpha concentrations greater than or equal to 500 U/mL. By contrast, rIL-2 enhanced proliferation at greater than 5 U/mL. When rIL-2 was combined with gamma IFN, an inhibitory effect on proliferation was observed, although to a lesser extent than gamma IFN alone. Pretreating the cells with 100 U/mL gamma IFN prior to rIL-1 or IL-2 exposure produced no change in the trends observed above.(ABSTRACT TRUNCATED AT 250 WORDS)

Cell Division↗
PubMed1988

Pressure distribution in the wrist joint.

We performed a study to determine pressure distribution properties of the normal radio-carpal joint. A system was developed for measurement of the contact pressure within the wrist joint surfaces. The transducer was based on Fuji pressure-sensitive paper, which was inserted into the joint space through a dorsal capsular incision. The hand was then positioned using a jig that permitted free axial loading of the joint. Each of five specimens was tested in 36 positions combining flexion/extension with radio/ulnar deviation and supination/pronation. The transducers were analyzed for contact area, scapho-lunate contact area ratio, pressure, and centroid locations using a microcomputer-based video-imaging system. The scaphoid and lunate contact areas on the radius and triangular fibrocartilage were separate and distinct in all wrist positions. Together these contact areas accounted for a relatively small fraction of the total joint surface area (average contact area/total joint area = 0.206, SD = 0.0495). For an applied 103 Newton compressive load, the high pressure averaged 3.17 MPa (SD = 0.83 MPa). Overall, the scaphoid contact area was 1.47 times that of the lunate, although variations occurred with position, as in flexion, in which the scaphoid/lunate area ratio was 0.83. The high-pressure centroids of both scaphoid and lunate contact areas shifted palmarly from 20 degrees of flexion to 20 degrees of extension and then dorsally with further extension. The scaphoid-lunate intercentroid distance averaged 14.91 mm with a range of 10-20 mm.

Carpal Bones↗
PubMed1987

A sluicing device for reproducibly measuring the strength of attachment of cultured cells to their substrate.

We assessed the strength of attachment of cultured human vascular endothelial cells to tissue culture plastic by controlled sluicing of cells, grown on multiwell plates, with isotonic saline using a specially designed nozzle attached to a reciprocating pump. Cells which were not dislodged were trypsinized and counted. The percentage of cells dislodged was proportional to the pump speed and to the volume of saline pumped. For given pump settings the proportion of cells detached was reproducible. The percentage of cells detached by sluicing increased at lower cell densities and decreased when the duration of trypsinizing of cells to be plated in multiwells, prior to sluicing, was increased. Our system is suitable for evaluating effects of biochemical interventions on the strength of cell attachment to the substrate.

Cell Adhesion↗
PubMed1987

Load transfer characteristics of the wrist. Part I. The normal joint.

A static positioning frame allows the positioning of unembalmed human upper extremities in any combination of wrist flexion/extension, radio/ulnar deviation, and pronation/supination. Pressure-sensitive film (Fuji) was used to study the contact areas, scaphoid-lunate area ratios, average high pressures, centroid positions, and intercentroid distances of five wrist joints under a uniform load of 103 Newtons (N) in 36 different positions. The contact areas accounted for only 20.6% of the available joint surface. They shift from a primarily palmar location to a primarily dorsal location when the wrist changes from flexion to extension. Overall the scaphoid contact area was 1.47 times that of the lunate and was generally greatest with the wrist in ulnar deviation. The scapho-lunate contact area ratio increased as wrist position changed from radial to ulnar deviation and/or from flexion to extension. For the constant load of 103 Newtons the high pressure averaged 3.17 megapascals (MPa). The scaphoid and lunate high pressure centroids shifted palmar when wrist position changed from 20 degrees of flexion to 20 degrees of extension and then shifted dorsal with further extension of the wrist. The intercentroid distance averaged 14.91 mm and ranged from 10 to 20 mm.

Biomechanical Phenomena↗
PubMed1987

Load transfer characteristics of the wrist. Part II. Perilunate instability.

An experimental model with a static positioning frame, pressure-sensitive film (Fuji), and a microcomputer-based video digitizing system, previously developed by the two senior authors, was used in this study to examine the effects of increasing perilunate instability on the load transfer characteristics of the wrist. These effects included a significant dorsal ulnar shift of the scaphoid centroid with increasing perilunate instability together with a less dramatic palmar ulnar shift of the lunate centroid. Overall, the scaphoid contact area was found to decrease as the stage of perilunate instability increased, even in ulnar deviation and/or extension, which in the normal wrist was found to be the positions that had the greatest scaphoid contact area. Average pressures in the high pressure zones were found to significantly increase in wrists with a stage III instability compared with normal wrists. An increase in the intercentroid (scaphoid/lunate) distance was most evident with the wrist in 20 degrees extension, neutral radioulnar deviation, and 90 degrees supination.

Biomechanical Phenomena↗
PubMed1986

A multi-facetted approach to externship evaluation.

The University of Toledo College of Pharmacy has developed a multi-facetted and dynamic system for evaluation of its Externship Program. The initial data base consisted of evaluation responses for individual externs, externship sites, and the performance records for the externship class of 1982 (N = 60/81). A list of behavioral objectives (competency statements) was constructed especially for institutional (hospital) pharmacies. A unique pre- and post-evaluation concept was developed as a control at each site. Externs were grouped by academic factors, work experience, and career plans. Each site was grouped by previous experience in training externs, the type of setting, and the intensity of service. This study discusses, summarizes, and makes recommendations from the results obtained through four distinct approaches.

Clinical Clerkship↗
PubMed1985

Mammography, sonomammography, and diaphanography (lightscanning). A prospective, comparative study with histologic correlation.

While mammography has become a routine method both for the screening and preoperative assessment of breast disease, the role of this modality, especially when compared with newer techniques of breast imaging, needs continued assessment. Recent advances using sonographic principles and diaphanography (light transillumination) must be compared with mammography to define specificity, sensitivity, and accuracy in assessing breast lesions. During a 16-month period between November 1982 and February 1984, 467 women with clinically apparent breast disease (symptoms or palpable lesions) were each studied using all three imaging techniques of mammography, sonomammography, and diaphanography. Of 168 women recommended for biopsy on the basis of these techniques, 84 women had histologic confirmation during this study period. Benign breast disease was diagnosed histologically in 38 women, while carcinoma was found in 46 patients. These techniques showed no significant differences in predicting benign or malignant disease when rates of sensitivity, accuracy, and specificity are computed. Diaphanography (lightscanning), allowed for consistently correct interpretation of cases proven to be histologically malignant and showed a false-negative rate comparable with x-ray mammography. We conclude that diaphanography is a sensitive indicator of both benign and malignant breast disease while serving as a reliable predictor of clinically apparent breast lesions without the potential problems of radiation exposure.

Adult↗
PubMed1981

Going private.

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England↗