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Biomedical subjects

C Hinton

Publications and source records attributed to C Hinton.

11 recordsLinked to original sources
PubMed1994

Selective processing of food and body size words: application of the Stroop Test with obese restrained eaters, anorexics, and normals.

The specificity of the retardation effect on the Stroop Naming task with eating disorder clients was examined by comparing anorexic patients and normal weight controls with obese restrained eaters. Although the expected differences between normal weight controls and anorexics were found for color naming of food and body size words, obese restrained eaters were not differentiated from the clinical sample. It is suggested, therefore, that the Stroop phenomena do not have a precise relationship to the extent of psychopathology and that factors such as the ability to "fake" the test and poor concentration leading to general slowing, may explain the results.

Adolescent↗
PubMed1990

Synchronous diffuse well-differentiated lymphocytic lymphoma and gastric adenocarcinoma presenting as splenomegaly and iron deficiency anemia.

Diffuse well-differentiated lymphocytic lymphoma (D-WDLL) and chronic lymphocytic lymphoma (CLL) represent closely related neoplasms which may have indolent courses. Dating back more than one century, reports of associated second primary malignancies continue to intrigue clinicians. A case of synchronous D-WDLL and gastric adenocarcinoma, presenting as splenomegaly and iron deficiency anemia, is presented. The case and literature are reviewed.

Adenocarcinoma↗
PubMed1987

Tumour aneuploidy, prognostic parameters and survival in primary breast cancer.

Cellular DNA content of primary tumours from 280 patients with operable breast cancer was determined by flow cytometry using nuclei from paraffin sections stained with DAPI, and 199 of these patients were followed for 8-13 years after surgery. Tumours from 67 patients have also been analyzed for their DNA content using single cell suspensions from fresh tumour tissue stained with mithramycin and ethidium bromide, and the results compared with those obtained from paraffin blocks of the same tumours. Overall 60% of the tumours contained cells with abnormal DNA content (DNA-aneuploid populations). Survival and disease free interval were not significantly different in patients with DNA-diploid and DNA-aneuploid tumours when analysed by Mantel's life table method. There was however, an early advantage for patients with DNA-diploid tumours: during the first 30 months after surgery DNA-aneuploidy was associated with higher rate of recurrence and shorter survival. DNA-aneuploidy was strongly related to histological grade. Thus 11/49 (22%) grade I, 60/102 (59%) grade II, and 96/129 (74%) grade III tumours were DNA-aneuploid. Although there was no significant difference in survival of patients with DNA-diploid and DNA-aneuploid tumours overall, there appears to be an unexpected association between DNA-aneuploidy and better survival in grade II patients (P less than 0.01); a similar trend was observed for grade I patients. Although the proportion of DNA-aneuploid tumours was similar in oestrogen receptor positive and negative tumours, DNA-aneuploidy was associated with lower levels of oestrogen receptors in comparison to DNA-diploid tumours. Comparison between the modal DNA values of fresh and paraffin embedded samples showed high rate of comparability (64/67, P less than 0.0001).

Aneuploidy↗
PubMed1987

Intra-articular variation of synovial changes in knee arthritis: biopsy study comparing changes in patellofemoral synovium and the medial tibiofemoral synovium.

Variation of synovial changes in the knee joint was studied in 23 patients. Histological features of biopsies taken from the patellofemoral joint synovium were compared with biopsies taken from the synovium of the medial tibiofemoral joint. The patellofemoral compartment showed more fibrosis compared to the medial tibiofemoral compartment where there was more inflammatory cell infiltration, pigmentation, an increase in vascularity, increased fragment deposition and synovial hyperplasia. Multiple biopsy with reference to compartmental localization is likely to give more information than biopsy of a single site.

Arthritis↗
PubMed1986

The effect of decalcified bone matrix on the osteogenic potential of bone marrow.

Rabbit bone marrow cells were cultured in diffusion chambers with or without decalcified bone matrix. The chambers were assayed after 28 days for alkaline phosphatase activity, deoxyribonucleic acid (DNA), calcium, and phosphorus contents. Morphologically, marrow cells incubated with or without matrix differentiated to form bone and cartilage. With bone matrix, the calcium and phosphorus contents of chambers were significantly higher than control chambers. Alkaline phosphatase activity and DNA content were not influenced by inclusion of bone matrix. These results indicate that bone matrix constituents exert a stimulatory effect on bone formation from marrow cells. This osteogenic stimulation could be due to the influence of an osteoinductive factor and/or to stimulation of osteoprogenitor cells known to be present in the marrow.

Alkaline Phosphatase↗
PubMedDate not supplied

Changing patterns of student nurse recruitment--1.

Just over 20 years ago, an attempt was made to determine to what extent schools of nursing provide recruitment information for potential candidates to nursing. The recruitment literature and application forms of 40 general hospitals and 20 psychiatric hospitals were analysed. A follow-up investigation was carried out 10 years later, in 1980, which sought to establish to what extent the recruitment process, in terms of information-provision and requisition, for potential nursing candidates had changed. The study was also expanded to include an analysis of the recruitment literature and application forms of 20 mental handicap hospitals. The conclusions from the initial study and the 1980 follow-up, together with a second follow-up study completed in 1990, are outlined here and in Part 2 next month, looking at the extent to which schools of nursing have changed their initial recruitment processes over the past 20 years.

Advertising↗
PubMedDate not supplied

Changing patterns of student nurse recruitment--2.

In 1970, a study was carried out to assess the type of information provided by schools of nursing to recruit prospective candidates to the profession. A follow-up study in 1980 showed that some response had been made to suggestions about particular types of information that potential recruits required (see Part 1, April 29). This week, in Part 2, the changes that have taken place in information exchange between 1980 and 1990 are assessed.

Adult↗