Hyperreactivity to histamine in the jejunum of veal calves with diarrhoea.
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Biomedical subjects
Publications and source records attributed to C Holzhauer.
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Bronchopneumonia of yearlings is a respiratory infection with bovine respiratory syncytial virus (BRS virus) occurring as a herd disease in young cattle. In severe cases, the clinical picture is identifiable; characteristic features are laboured respiration and a high morbidity rate. Following an acute onset, atypical interstitial pneumonia is observed on postmorten examination and bacteriological studies are negative. An attenuated live BRS virus vaccine was used against bronchopneumonia of yearlings in 1976, 1977 and 1978. This vaccine was inoculated in twenty-six herds supervised by the present author and numbering approximately 1,200 animals in the sensitive period of life. Moreover, the results obtained by sixty practitioners on vaccinating approximately 13,000 animals in 1978 were collected. Conclusive evidence of the effectiveness of the vaccine was not provided by these field trials. However, it is concluded from the findings that the satisfactory results obtained in the majority of cases were not accidental and that these results suggest that BRS virus vaccine is very likely to have a protective action against bronchopneumonia of yearlings.
Findings on infectious bovine rhinotracheitis (IBR) since this disease was diagnosed for the first time in the province of Gelderland in 1973, are reported. The clinical picture varies markedly, unmistakable symptoms are followed by a period of impaired health in a number of cases. There is no evidence to suggest that this impaired state of health is due to the causative virus of IBR. The number of infected herds is constantly increasing and is currently estimated at approximately 20 per cent. The disease also shows an increasing incidence in veal-calf herds. Intranasal vaccination will afford adequate protection of other members of the herd in the event of IBR but the immunity produced is short-lived.
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The clinical picture of "pinkengriep", an enzootic form of bronchopneumonia in young cattle, is described. In addition to cough, conjunctivitis and a soporous state, accelerated respiration initially is an outstanding clinical symptom. In some cases, symptoms of fog fever appear during the second stage of the disease. In the autumn of 1973 and that of 1974, a total number of 292 animals with "pinkengriep" were serologically examined for known respiratory virus infections and Chlamydia. Complement fixation tests showed that there was significant increase in antibodies to respiratory syncytial virus in 76 per cent of the animals studied. In the case of para-influenza virus 3, virus diarrhoea virus, the adenoviruses of the antigen groups 1, 2 and 3, those of the antigen groups 4 to 10 inclusive and Chlamydia, these proportions were 48, 13, 12, 11 en 10 per cent respectively. On the other hand, symptoms of infection with infectious bovine rhinotracheitis virus were absent in the herds studied. These findings suggest a possible role of bovine respiratory syncytial virus in "pinkengriep".