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Biomedical subjects

C Howe

Publications and source records attributed to C Howe.

24 records · Page 2Linked to original sources
PubMed1977

Properties of influenza C virus grown in cell culture.

Influenza C virus was propagated successfully in primary chicken embryo lung (CEL) and fibroblast cells and in Madin-Darby canine kidney (MDCK) cells. In other cell lines, either no virus or only noninfectious hemagglutinin (HA) was produced. In productively infected cells (CEL), HA and infectious virus appeared by 24 h and reached a maximum by 36 to 48 h, cell-associated virus remaining at a constant low level. Infected Vero cells produced noninfective HA by 24 h which also remained predominantly cell associated until 60 to 72 h, when the cells disintegrated. Viral antigen was demonstrable on membranes of both CEL- and Vero-infected cells at 24 h; Vero cells yielded membrane vesicles containing HA, but none of the spherical or filamentous viral particles synthesized in CEL cells. Influenza C virus produced in cell culture or in eggs differed in several important respects from A and B viruses and from Newcastle diseases virus. All influenza C preparations, regardless of infectivity or source, lacked detectable neuraminidase activity, yet retained the ability specifically to inactivate receptors only for influenza C. Influenza C HA was not inhibited by soluble glycoproteins highly active against HA of A virus. A rat serum glycoprotein uniquely inhibited influenza C by binding to the surface components of virious.

Blood Proteins↗
PubMed1976

Pseudopneumoperitoneum: a case report.

A case of post-traumatic pseudocyst of the pancreas is presented. The elevated and compressed stomach showed an appearance on X-ray film which might be interpreted as free peritoneal air. The term pseudopneumoperitoneum is defined and other causes of this condition are mentioned.

Adult↗
PubMed1976

Light and drug induced changes of epiphysial synaptic ribbons.

In the present investigation experiments were carried out to determine whether the functionally obscure synaptic rebbons of mammalian pinealocytes can be affected by acute changes in environmental lighting and which chemical processes may be involved in their regulation. Experiments carried out in male guinea-pigs have shown that the amounts of synaptic ribbons are immediately affected by changes in the lighting pattern. Extension of the light period reduced the normally occurring increase, whereas extension of the dark period inhibited the normally occurring decrease in the amount of synaptic ribbons. Results following injections of a number of drugs known to influence pineal function (noradrenaline, L-DOPA, propranolol, reserpine and p-chlorophenylalanine, respectively) suggest that synaptic ribbons may be directly or indirectly regulated by beta-adrenergic mechanisms.

Animals↗
PubMed1976

Identification of receptors for animal viruses.

Present knowledge of cell surface receptors for animal viruses is reviewed. The methods used for enumeration and identification of receptors are critically examined with respect to particular advantages and disadvantages. Specific controls and alternative interpretations are suggested in connection with the reactions of lectins which block viral attachment to cells. Currently available information for each group of animal viruses is summarized in order to define the extent to which the corresponding receptors have been identified. It is concluded that the full range of virus-receptor interactions has not yet been explored even for those viruses of which there is the most detailed knowledge. For some groups, moreover, the receptor is totally uncharacterized. Six areas in which future investigative effort might be productive are identified, including the isolation of membrane components and the immunochemical definition of viral receptors.

Binding Sites↗