Biomedical subjects

C I Roberts

Publications and source records attributed to C I Roberts.

10 recordsLinked to original sources

PubMed1996

Adult Chiari malformation with headache and trigeminal dysesthesia.

Arriving at a correct diagnosis in some cases of facial pain and headache can test the time, patience, and diagnostic skills of any clinician. When the symptoms are diffuse with few localizing signs, it is easy to attribute pain to a functional origin. The case described underlines the importance of careful clinical examination and the use of magnetic resonance imaging, which proved the only positive diagnostic aid in this instance. The value of magnetic resonance imaging in redefining Chiari malformations is discussed and the question of appropriate interpretation of findings aired.

Adult↗

PubMed1982

Plasma melphalan and prednisolone concentrations during oral therapy for multiple myeloma.

Nine patients with myeloma were studied over 13 oral administrations of 10 mg melphalan and 5-10 mg prednisolone. Plasma melphalan concentrations were estimated by high-pressure liquid chromatography, prednisolone concentrations by quantitative thin-layer chromatography. The mean plasma half-life of unchanged melphalan was 0.9 +/- 0.5 (SD) h. The 'lag-time' before melphalan was detected in the plasma varied from 1 to 4 h, the mean peak concentration was 96 +/- 21 ng/ml, and the mean area under the plasma concentration by time curve was 160 +/- 78 ng h/ml. This variability was consistent with observations made elsewhere following much higher oral doses of melphalan and illustrates the relatively wide interindividual variability of absorption. Observations made in the same subjects on two separate occasions showed lower variability. The melphalan elimination rate was not significantly affected by moderate impairment of creatinine clearance (to 31 ml/min). Absorption of prednisolone in five of these patients was apparently normal and unaffected by concurrent administration of melphalan.

Adult↗

PubMed1972

Intraabdominal abscesses due to azathioprine for Crohn's disease.

We report here a case of Crohn's disease in which there is strong circumstantial evidence that azathioprine precipitated the development of an intraabdominal abscess on two separate occasions. On both occasions, the abscess developed within a few weeks of the patient starting azathioprine, and complete healing occurred on stopping azathioprine. The patient had never previously had this complication. On both occasions, the only early indications of a developing infection were the appearance of toxic granulation of neutrophils in the peripheral blood and a progressively rising erythrocyte sedimentation rate.

Abdomen↗

PubMed1972