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Biomedical subjects

C Ibukiyama

Publications and source records attributed to C Ibukiyama.

9 recordsLinked to original sources
PubMed1990

[Evaluation of latent cardiac disease in diabetic patients with Tl-201 exercise myocardial scintigram and blood pool scintigram].

To find latent heart disease in diabetic patients, 142 diabetic patients were divided into 4 groups: 1) No hypertension and normal ECG (DM group); 2) Hypertension recognized clinically (HT group); 3) Myocardial damage on ECG (MD group) 4) group associated with the previous 2 (HT + MD group). In all groups Tl-201 exercise myocardial scintigrams and blood pool scintigrams were taken for comparative analysis. Positive rates of SPECT were 27.7% (23/83) in the DM group, 30.0% (9/30) in the HT group, 50.0% (6/12) in MD group, and 70.6% (12/17) in the HT + MD group. The rate in the HT + MD group was significantly higher than in that of the DM and HT groups (p less than 0.001, p less than 0.01). Blood pool scintigrams revealed that in the HT + MD group, as compared with the normal control group, both 1/3 FF and PFR were significantly depressed, in addition to significant TPF prolongation in the former (p less than 0.001, p less than 0.05, p less than 0.05). These findings suggest that in diabetic patients hypertension and myocardial damage would lead to a high incidence of abnormality in SPECT and left ventricular rapid filling dysfunction. This indicate a high incidence of latent cardiac disease which can be recognized in diabetic patients by stress myocardial and blood pool scintigrams.

Adult↗
PubMed1989

Effect of sodium intake on the hypotensive effect of calcium antagonists.

To clarify the influence of Na balance on the hypotensive effect of calcium antagonists, the changes of blood pressure and humoral factors after a single oral administration of 40 mg nicardipine were evaluated in 15 subjects with essential hypertension under high, normal, and low Na regimens (mean 24 hour urinary Na excretion: 320 +/- 24, 147 +/- 7, 27 +/- 6 mEq, respectively). Nicardipine induced a significant reduction of mean blood pressure and increase in heart rate. The change of mean blood pressure after nicardipine was negatively related to the pretreatment mean blood pressure under the three levels of Na intake (p less than 0.01). The slopes of the correlation lines for high, normal, and low Na regimens were -0.61, -0.69, and -0.52, respectively, without statistical significance. Nicardipine brought about significant increases in plasma renin activity and plasma norepinephrine, but no changes in plasma levels of epinephrine, 6-keto-prostaglandin F1 alpha, thromboxane B2 or serum aldosterone concentration. These results suggest that the magnitude of the untreated blood pressure and thereby the peripheral resistance are major determinants of the blood pressure fall caused by calcium antagonists, and that the failure to increase aldosterone and epinephrine in the face of peripheral vasodilation may be responsible in part for the hypotensive effect of this drug.

6-Ketoprostaglandin F1 alpha↗
PubMed1989

[Validity of estimating left ventricular relaxation and filling dynamics by Doppler trans-mitral flow].

To evaluate the validity of estimating left ventricular (LV) diastolic function using the Doppler transmitral flow profile, the relationship of transmitral flow to LV relaxation and LV filling dynamics was observed. A total of 54 subjects, including patients with ischemic heart disease, idiopathic cardiomyopathy, and normal persons were examined. LV filling dynamics were assessed in 20 of them who had no regional wall motion abnormality or irregular LV geometry. Peak velocity of rapid filling (R) and acceleration of rapid filling (AR) at the mitral annular level were measured as indices of transmitral flow during the rapid filling period. LV relaxation was evaluated according to the time constant of LV isovolumic pressure decline (T) using the method of Weiss et al. The correlation coefficient between R and T was -0.27 and that between AR and T was -0.16, indicating lack of correlations. The v-wave of pulmonary wedge pressure (PWPv) was measured as an index for left atrial driving pressure during the rapid LV filling period. Multiple regression analyses of R or AR as dependent variables and T and PWPv as independent variables revealed significant correlations (r = 0.66 and r = 0.59). The peak transit rate (PTR = R/TVI) and atrial transit fraction (ATF = TVIa/TVI) were determined from the time integral of the transmitral flow velocity (TVI = time velocity integral during diastole, TVIa = time velocity integral during the atrial contraction phase). Also, the peak filling rate (PFR) during the rapid filling and atrial filling fraction (AFF) were determined by left ventriculography.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

Radionuclide angiography in pulmonary sequestration.

We report a case diagnosed as pulmonary sequestration by radionuclide angiography prior to operation which showed anomalous arteries. Radionuclide angiography clearly revealed the condition of both the pulmonary artery and aorta, and is considered to be extremely useful in the diagnosis of pulmonary sequestration. It will probably be applied to more patients in the future.

Aorta, Thoracic↗
PubMedDate not supplied

A coordinate axis transformation study of spatial QRS loop in hypertrophic cardiomyopathy.

To obtain an overall view of the QRS loop on vectorcardiograms (VCG) of hypertrophic cardiomyopathy (HCM), the coordinate axis was transformed using the resolver method. The morphological features and planarity of the loop were compared with hypertrophic patterns and hypertensive heart disease (HHD). The subjects in the present study included 30 normal individuals, 40 patients with HCM and 30 with HHD. The HHD group was selected from patients showing left ventricular hypertrophy on VCG similar to that of HCM patients. The HCM group showed significantly greater values than the HHD group in the thickness/length ratio, which represents the planarity of the spatial QRS loop. The above finding suggests that the HCM group had greater deformation in the QRS loop than the HHD group. This may provide a useful indicator for the differential diagnosis of the two diseases.

Adult↗
PubMedDate not supplied

Experimental study on enzyme distribution and its relation to myocardial ischemic changes following coronary circulatory disturbances.

Coronary artery ligation of canine heart was performed to investigate the relationship between the lactate dehydrogenase (LDH) pattern in myocardium and the distribution of coronary flow, especially in the early stage of ligation and after reperfusion. In the myocardium of normal dogs, the LDH pattern was similar in the left ventricle, the interventricular septum, and the right ventricle; the average LD5:LD4 ratio was 1.1, 1.2, and 1.2, respectively, and consisted mainly of heart type. In the left and right auricles, however, the ratios were 0.3 and 0.2, respectively, lacking heart type. In the left ventricle, LD5:LD4 ratio in the subendocardium was different from that in the subepicardial layer. Blood flow distribution in canine myocardium was investigated by the fluorescent pattern on the cut surface of heart, in which 10% fluorescein sodium was injected into the cavity. By this method the evolution of the ischemic area from the endocardial layer to the epicardial side following coronary artery ligation and the effect of reperfusion on the ischemic area were clarified. Electron microscopic studies indicated that loss of mitochondrial function may account for the irreversibility of myocardial cell alteration. A new method for studying enzyme localization in tissues was introduced for studying LDH isoenzyme distribution in normal and injured myocardium.

Animals↗