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Biomedical subjects

C Itakura

Publications and source records attributed to C Itakura.

At least 127 records · Page 7Linked to original sources

Renal secondary hyperparathyroidism in aged Sprague-Dawley rats.

Fourteen aged Sprague-Dawley rats had typical renal secondary hyperparathyroidism. The renal disease was severe glomerulosclerosis with tubular dilation. The parathyroid glands were enlarged and had hyperplasia of chief cells. Bone lesions were generalized osteodystrophia fibrosa and osteosclerosis. All rats had osteodystrophia fibrosa and it was severe in 10 rats. Only four rats had osteosclerosis and it was moderate. Metastatic calcification was seen in various soft tissues in 13 rats.

Age Factors↗

Pathology of spontaneous hemorrhagic enteritis of turkeys.

Thirteen turkeys naturally affected with hemorrhagic enteritis were studied pathologically. The main gross lesions were splenomegaly and hemorrhagic contents in the gut. The main histological lesions were intranuclear inclusion bodies in largemononuclear cells in many visceral organs and in reticular cells around the sheathed arteries of the spleens and varying degrees of lymphocytic hyperplasia in most tissues. The inclusions were frequently present in areas of the lymphocytic hyperplasia. The large mononuclear cells with the inclusions frequently showed a degenerative change.

Animals↗

Electron microscopic findings of cells with inclusion bodies in experimental hemorrhagic enteritis of turkeys.

The spleen, liver, bone marrow and intestines of two turkeys in which hemorrhagic enteritis of turkeys was experimentally reproduced were examined electron-microscopically. Intranuclear inclusion bodies as described in a previous report were found in all the tissues examined. These occupied most of the area in affected nuclei and were composed of viral particles with morphological characteristics of an adenovirus. The cells with the inclusions were divided into two types of cells, immature and reticular cells. There was some variety in the stage of differentiation of the former cells. As the viral particles developed the cells degenerated and disintegrated. A few particles had been released into the cytoplasm of the degenerated cells but no particles were present in intercellular spaces.

Adenoviridae↗