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Biomedical subjects

C J Cockerell

Publications and source records attributed to C J Cockerell.

At least 127 records · Page 7Linked to original sources
PubMed1989

Microcystic adnexal carcinoma of the scalp.

Microcystic adnexal carcinoma (MAC) is a recently described rare adnexal neoplasm showing benign histologic features but a locally aggressive behavior. It has most commonly been reported to occur on the face but it has also been noted in the axilla and buttock. We describe a 41-year-old white male with a 5-year history of MAC on the scalp and treatment by Mohs micrographic surgery. To our knowledge, this is the first case of MAC reported to occur on the scalp.

Adult↗
PubMed1989

Skin manifestations of HIV infection.

The skin is quite commonly involved in patients with HIV infection and the resulting diseases may serve as presenting signs of AIDS or ARC. The most common infectious and non-infectious inflammatory disorders as well as common neoplasms that are seen in this patient population are reviewed and depicted in detail.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Epithelioid angiomatosis: a distinct vascular disorder in patients with the acquired immunodeficiency syndrome or AIDS-related complex.

Unusual cutaneous vascular neoplasms distinct from Kaposi's sarcoma were observed in five patients with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 infection. The cutaneous lesions were solitary or multiple papules and nodules. In some patients the lesions also affected internal organs. Histologically the neoplasms were composed of proliferating blood vessels and cells with epithelioid features. Immunoperoxidase studies of one lesion showed that the cells expressed both factor VIII antigen, a maker for endothelial cells, and alpha 1-anti-chymotrypsin, a marker for histiocytes. In some patients the lesions gradually disappeared but in two they were the cause of death, in one case from disseminated intravascular coagulation and in the other from laryngeal obstruction by the tumour.

AIDS-Related Complex↗
PubMed1986

Seborrheic-like dermatitis of acquired immunodeficiency syndrome. A clinicopathologic study.

We studied twenty-five skin biopsies from twenty-one patients with acquired immunodeficiency syndrome or its prodrome who presented with the "seborrheic dermatitis" associated with acquired immunodeficiency syndrome and compared them with an equal number of biopsies from patients with seborrheic dermatitis who had neither acquired immunodeficiency syndrome nor its risk factors. We found that although the eruption in acquired immunodeficiency syndrome closely resembles seborrheic dermatitis, histologically it is distinctive because it shows spotty keratinocytic necrosis, leukoexocytosis, and a superficial perivascular infiltrate of plasma cells and, frequently, neutrophils that show occasional leukocytoclasis. In long-standing lesions, hyperkeratosis is often present. None of these histologic features are commonly encountered in seborrheic dermatitis, psoriasis, or other eruptions known to us.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Papules.

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Biopsy↗
PubMed1986

Plaques.

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Humans↗
PubMed1985

A retrospective look at dysplastic nevi. What were they in 1978 and how have they fared since?

We re-examined histologic sections of 305 melanocytic lesions consecutively received for diagnosis in 1978. Of 237 lesions previously diagnosed as banal melanocytic nevi, 28% were reinterpreted to be dysplastic nevi. Clinical follow-up 5 years later of 28 incompletely removed dysplastic nevi revealed neither persistence of pigment nor development of malignant melanoma at their sites of biopsy. We conclude, therefore, that dysplastic melanocytic nevi were common melanocytic neoplasms in 1978. Furthermore, based on our findings, they may be managed safely by observation with periodic clinical follow-up. Of 61 malignant melanomas studied during the same period in 1978, none occurred in association with a dysplastic nevus. The concept that malignant melanomas commonly arise in dysplastic melanocytic nevi therefore should be re-examined.

Diagnosis, Differential↗
PubMed1985

Macules.

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Humans↗