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Biomedical subjects

C J Craig

Publications and source records attributed to C J Craig.

11 recordsLinked to original sources
PubMed1990

The taking of adequate cervical smears.

In order for cytological examination of a cervical smear to be an adequate method of screening for pre-invasive lesions, the smear must contain both squamous and endocervical cells. Figures obtained for 1988 indicated that in South Africa 45% of smears do not contain endocervical cells. The study reported, in which the same patients were compared in successive years but using different techniques, showed that with the use of biomedically designed tools 98.3% of smears can be classified as adequate.

Evaluation Studies as Topic↗
PubMed1984

Management of patients with a diastolic blood pressure of 90 mmHg in the third trimester of pregnancy.

A retrospective study of 50 patients admitted to the Peninsula Maternity Hospital, Cape Town, with a diastolic blood pressure of 90 mmHg was carried out. Proteinuria and a serum urate level of 0,36 mmol/l or more were found to be risk factors in this group. It is suggested that these patients can be managed as outpatients if no proteinuria is present and the serum urate level is less than 0,36 mmol/l; they should be trained to test urine at home and should be followed up on a weekly basis. A small prospective study showed that home urine testing was both workable and satisfactory.

Blood Pressure↗
PubMed1983

Obstetric complications in adolescent pregnancies.

Teenage and pre-teenage pregnancies in 128 patients less than 16 years of age were studied retrospectively. Obstetric outcome was analysed and compared with that in previous studies. Pregnancy-induced hypertension, premature labour and anaemia were significant complications in this group. Perinatal mortality was not increased and there was no evidence of an increased obstetric risk in the very young teenager, but earlier booking and better antenatal counselling are necessary.

Adolescent↗
PubMed1983

Effect of clorgyline (a MAO type A inhibitor) on locomotor activity in the Syrian hamster.

Syrian hamsters in a lighting schedule of 14 h of light per day (LD 14:10) and housed in cages equipped with running wheels exhibited a clear onset of locomotor activity during the 1st h after lights off. Implantation of osmotic minipumps containing clorgyline (2 mg . kg-1 . day-1), an irreversible inhibitor of monoamine oxidase type A, caused a 1.5-h delay in the onset of wheel running by the 7th day of treatment. Increasing dosages of clorgyline (0.5, 1, 2, or 4 mg . kg-1 . day-1) caused increasing delays. Hamsters shifted from LD 14:10 to LD 10:14 underwent a 3-h advance in the onset of wheel running. Animals treated with clorgyline (2 mg . kg-1 . day-1) exhibited a markedly slowed rate of advance in activity onset, which did not prevent the short photoperiod from inhibiting reproductive function. Additionally, removal of the pineal gland did not affect wheel-running onset and did not prevent the delay in activity onset during clorgyline treatment. Hamsters in LD 14:10 were "released" into constant darkness (DD) for 3 days to prevent masking of activity onsets and offsets by light. Delays in activity onset in LD 14:10 caused by clorgyline (2 mg . kg-1 . day-1) persisted when these animals were released into DD. Activity offset in LD 14:10 occurred at lights on before and during clorgyline treatment but was delayed when the treated animals were maintained in DD. Drug-induced delays in both activity onset and offset suggest that clorgyline is not simply shortening the duration of activity or changing the expression of activity relative to the light-dark cycle, but is delaying the phase position of the circadian rhythm in locomotor activity. Clorgyline may act directly on the central oscillatory mechanism that drives the rhythm.

Animals↗
PubMed1980

The essential place of colposcopy in gynaecological practice.

If routine cytoloical examination of a cervical smear reveals an abnormality short of invasive carcinoma, colposcopic examination, plus directed biopsy of the cervix, is the procedure of choice. Cytological examination is a laboratory technique, whereas colposcopy is a clinical diagnostic method. When the latter is used, anaesthesia and hospital admission are not required, and the hazards and limitations of cone biopsy of the cervix are avoided. The technique of colposcopy is a significant advance in gynaecology, and training in this method should be part of the curriculum for a higher qualification in gynaecology.

Biopsy↗