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Biomedical subjects

C J Day

Publications and source records attributed to C J Day.

18 recordsLinked to original sources
PubMed2000

Visible and occult blood contamination of laryngeal mask airways and tracheal tubes used in adult anaesthesia.

The purpose of this study was to compare visible and occult blood contamination of 50 laryngeal mask airways and 50 tracheal tubes following routine anaesthesia for procedures not involving the oropharyngeal or nasal cavities. All airway devices were examined visually for the presence of blood before washing in 100 ml of water. A semiquantitative dipstick was used to test for the presence of blood in the washings. Laryngeal mask airways were examined visually by both authors to test agreement. The results show that occult blood contamination occurred in 78% of tracheal tubes and 76% of laryngeal mask airways, while visible blood contamination was 16% and 12%, respectively. Other studies reporting visible blood contamination of airway devices probably underestimate the true incidence of blood contamination. Oral secretions following the use of these devices should be considered as high risk for transmission of blood-born viruses. Anaesthetic and recovery staff should be protected against the risks of occupational exposure to oral secretions following the use of airway devices.

Adult↗
PubMed1999

The impact of percutaneous tracheostomy on intensive care unit practice and training.

We studied the impact of introducing percutaneous tracheostomy to our intensive care unit on the incidence and timing of tracheostomy and on the implications for surgical training. The proportion of patients receiving intensive care who underwent tracheostomy doubled from a median of 8.5% to 16.8% (p < 0.01) following the introduction of the percutaneous technique with the procedure being undertaken significantly earlier during the intensive care stay. The opportunity for surgical trainees to gain experience in open surgical tracheostomy has been virtually lost. The increase in tracheostomy rate may reflect a previous under-utilisation caused by the logistic problems of transferring a critically ill patient to theatre, or alternatively a relaxation of the indications for tracheostomy caused by a perceived benefit for the patient. An increased workload may also have contributed to the rise. Surgical trainees should be encouraged to learn percutaneous techniques and training opportunities in open surgical techniques should be maximised.

Critical Care↗
PubMed1998

Hospital mortality after urgent and emergency laparotomy in patients aged 65 yr and over. Risk and prediction of risk using multiple logistic regression analysis.

We studied 107 patients aged over 65 years undergoing urgent or emergency laparotomy. Aspects of preoperative assessment, perioperative management and postoperative care were analysed by multiple logistic regression to determine the factors that predicted hospital survival. We determined which factors influenced anaesthetists' prediction that patients would survive. These predictions were made both before and immediately after operation. The factors associated with the use of invasive cardiovascular monitoring were also studied. We obtained a model that accounted for 93% of the variability in the likelihood of survival. Age and ASA status were significant predictors of survival (P < 0.05), and of anaesthetists' prediction of mortality both before and after operation. Several other factors were significant determinants of survival but were not determinants of the anaesthetist's opinion regarding survival.

Aged↗
PubMed1996

The effects of cardiopulmonary bypass temperature on neuropsychologic outcome after coronary artery operations: a prospective randomized trial.

UNLABELLED: The effect of systemic perfusion temperature on postoperative cognitive function was investigated in 96 adult patients undergoing elective coronary revascularization with cardiopulmonary bypass at 28 degrees C, 32 degrees C, or 37 degrees C. Neuropsychologic performance was assessed 1 day before the operation and 6 weeks after the operation. Five tests were adapted from the Wechsler Adult Intelligence Scale and two from the Wechsler Memory Scale. RESULTS: No patients had major neurologic complications. Ninety-three patients completed the five Wechsler Adult Intelligence Scale tests, but only 70 went on to complete the Wechsler Memory Scale tests as well. In these, there was an effect of cardiopulmonary bypass temperature on the number of neuropsychologic tests in which there was a preoperative to postoperative deterioration (p = 0.021), the number with bypass at 37 degrees C being significantly greater than the number with bypass at 32 degrees C (p = 0.015). Subsidiary analyses using a multivariate linear model examined the effect of cardiopulmonary bypass temperature on the magnitude of change, with or without allowing for other possible confounding influences. There was an adverse effect of normothermic (37 degrees C) versus moderately hypothermic (32 degrees C) perfusion---more convincingly displayed in the analyses of all seven scores rather than just the Wechsler Adult Intelligence Scale scores. Further cooling to 28 degrees C conferred no additional benefit in terms of cognitive function. The importance of the deterioration is open to question.

Body Temperature↗
PubMed1994

Traumatic pneumomyelogram. Implications for the anaesthetist.

A 70-year-old man sustained a severe head injury following a fall downstairs, which resulted in him being found in a head down position. In the accident and emergency department he was noted to have subarachnoid air on a lateral cervical spine radiograph. This drew attention to the presence of fractures in the middle cranial fossa and nitrous oxide was immediately discontinued. The presence of a traumatic pneumomylogram implies a base of skull or middle cranial fossa fracture, and is almost certainly associated with intracranial subarachnoid air. Early recognition of the condition, and cessation of nitrous oxide, is essential to prevent dangerous increases in intracranial pressure secondary to the diffusion of gas into the air filled cavity.

Accidental Falls↗
PubMed1978

Morphological characterization of Kupffer and endothelial cells of rat liver isolated by counterflow elutriation.

Kupffer and endothelial cells of rat liver were purified by recirculating collagenase perfusion, metrizamide gradient, and counterflow elutriation. Every step of the isolation procedure was followed by light microscopy and histochemistry. The final fractions of purified sinusoidal cells were examined in their isolated state by transmission and scanning electron microscopy. The scope of this manuscript is the detailed documentation and discussion of all technical aspects and problems of a rather new isolation technique, as well as the detailed description of the purified sinusoidal cells of the liver by scanning electron microscopy. Broader acceptance of this isolation procedure should lead to the specific characterization of biochemical and immunological functions of these cells and elucidate their pathophysiological significance.

Animals↗
PubMedDate not supplied

New developments in the pathogenesis of ANCA-associated vasculitis.

In recent years there have been substantial developments in the understanding of the pathogenesis of ANCA-associated vasculitidies. Animal models have now been developed that finally prove a direct pathogenic role for ANCA, a subject fiercely debated since their original identification. We are also closer to understanding how ANCA exert their effects to cause disease. Progress has been made in elucidating how ANCA activate neutrophils, from how they bind antigen and where that antigen is located, to how antigen binding is translated into intracellular activity. The effects of ANCA activation on the effector functions of neutrophils and monocytes are being further dissected and the flow-based assay is allowing interactions with endothelium to be studied in more detail. Knowledge of the role of T cells has been enhanced by examining contributions to disease by differing subsets and their cytokine secretions. Defects in apoptosis playing a role in the initiation of other autoimmune diseases has prompted investigations into whether a similar pathogenesis is relevant in vasculitis, and various genetic polymorphisms have been discovered to be important in determining in whom vasculitis develops. This article reviews how recent research has helped in the understanding of the pathogenesis of small vessel vasculitis.

Animals↗
PubMedDate not supplied

Auditory, ocular, and facial complications of central neural block. A review of possible mechanisms.

BACKGROUND AND OBJECTIVES: The purpose of this review is to draw together a collection of uncommon complications of central neural block that affect the cranial nerves. There have been a small number of case reports, some of which have included a possible mechanism of the nerve dysfunction, but there is no prior review that collected them together and discussed the possible mechanisms. METHODS: Published case reports were identified by searching Medline of the British Medical Association and the Silver Platter CD-ROM library. In addition, the Medical Defence Union and Medical Protection Society were contacted to find cases that were unpublished but the subject of medical negligence lawsuits. RESULTS: The authors collected these cases together to increase awareness of alarming complications. If such cases are recognized for what they are, then the prognosis is good; however, delayed diagnosis can make them a cause of great anxiety and possible litigation. CONCLUSIONS: Increased awareness of these complications can decrease the likelihood of litigation by early diagnosis and explanation. Their mechanisms are not fully understood but the likely possibilities have been discussed. Further work is needed to establish the incidence of these problems, as it is likely that many cases are not diagnosed and not reported.

Anesthesia, Epidural↗