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C J De Groot

Publications and source records attributed to C J De Groot.

46 records · Page 3Linked to original sources
PubMed1982

Plasma phenylalanine and tyrosine levels during the day in normal female controls and female obligate phenylketonuria heterozygotes.

The plasma phenylalanine and tyrosine levels of 8 female obligate phenylketonuria heterozygotes and 8 female controls have been measured over a 7-hour period during the day. No significant differences were observed in the plasma tyrosine levels. It is concluded that the supply of tyrosine to the growing fetal brain is not necessarily impaired by the decreased ability to convert phenylalanine to tyrosine of the phenylketonuria heterozygous mother.

Female↗
PubMed1981

Trace element studies in three patients and a fetus with Menkes' disease. Effect of copper therapy.

This paper reports the results of a multielement analysis of postmortem samples of Menkes patients, of which one was untreated and two had been treated for various lengths of time with intramuscular injections of copper-EDTA. The findings have been compared with data from a Menkes fetus and from controls. The results confirm that copper accumulates in various tissues and demonstrate a further increase in copper levels as a result of the treatment with copper-EDTA. Although no clinical improvement was observed, the levels of some copper-containing enzymes normalized during the copper-therapy. Furthermore, in agreement with the identification of the copper-binding protein in the kidney as metallothionein, it was found that not only copper, but also zinc, cadmium, and mercury are trapped in this tissue. A low copper concentration in the brain was also found in a Menkes fetus, indicating that brain damage might already have occurred before birth. Speculation Until recently, Menkes' disease was considered to be due to copper deficiency. However, the symptoms are more typical of a storage disease in which copper is irreversibly trapped in some tissues, in particular in the kidneys, by metallothionein. This abnormal storage pattern gives rise to copper deficiency elsewhere in the organism, particularly in the brain where it may cause irreversible damage in the foetus. Parenteral administration of copper does not lead to clinical improvement. The only "therapy" that seems feasible at present is tracing the carriers of the disease and advising abortion when prenatal diagnosis indicates a male fetus carrying the disease.

Arsenic↗
PubMedDate not supplied

Umbilical cord: factors which influence the separation time.

The separation time of the umbilical cord was studied in 98 healthy Indonesian newborns with the aim of determining the normal time of separation and to evaluate factors which may influence it. The authors looked for a relationship between cord separation and sex, birthweight, gestational age, parity of the mother and nutrition of the newborn. Mean separation time was 10.9 days (S.D. 3: range 5-23 days). None of the factors analysed had a statistically significant influence. Cord care consisted of triple dye; no umbilical infections were found.

Birth Weight↗
PubMedDate not supplied

Umbilical cord length and intra uterine wellbeing.

The length of the umbilical cord was studied in 179 Indonesian newborns to determine the normal range of cord length and its influence on the occurrence of intrapartum complications such as meconium stained amniotic fluid, asphyxia and entanglement of the cord around the fetus. The authors also attempted to investigate whether unfavourable intra uterine conditions could influence cord length. Therefore a correlation between cord length, sex, gestational age, birthweight and head-circumference was sought. The mean length of the umbilical cord was 52.2 cm., with a S.D. of 10.2 cm, ranging from 31-100 cm. Male infants had significantly longer umbilical cords than females (p = 0.02). The risk of complications increased parallel with cord length.

Birth Weight↗