PubMed HealthSearch

Biomedical subjects

C J Goeller

Publications and source records attributed to C J Goeller.

2 recordsLinked to original sources

A microcomputer-based sleep stage analyzer.

A microcomputer-based sleep stage analysis system for laboratory use is described. Rapid spectral analysis of the electroencephalogram (EEG) is achieved through hardware; subsequent analysis, including determination of the relative power in user-defined EEG frequency bands is provided through software. A decision matrix, based on standard sleep state analysis criteria, enables these spectral data, in conjunction with integrated electromyogram (EMG) power, to determine sleep stages. The system has been configured here to quantify standard sleep stages, but the algorithm can also identify, and provide information about, EEG states which are not easily classified according to earlier criteria used for visual classification of polygraphic records. This low-cost, user-friendly system thus achieves flexible, quantitative analysis of EEG and EMG signals.

Animals

Partial reversal of barbiturate anesthesia by dopamine antagonism: an electroencephalographic study.

The D-1 dopamine antagonist, SCH 23390, was administered to rats under barbiturate anesthesia. Recording of the power frequency spectrum of the electroencephalogram (EEG) showed that the D-1 antagonist shifted the relative power in the EEG to higher frequencies. In contrast, a relatively selective D-2 antagonist, haloperidol, administered under the same conditions, had no effect. These results suggest that SCH 23390 can partially reverse barbiturate anesthesia, and imply that central dopamine, acting at the D-1 site, might modulate this type of anesthetic.

Anesthesia