Biomedical subjects

C J Grant

Publications and source records attributed to C J Grant.

9 recordsLinked to original sources

PubMed1983

Plasmapheresis in Rh hemolytic disease: the danger of amniocentesis.

We have treated 25 women with poor obstetric histories and high levels of anti-Rh antibodies by plasmapheresis during pregnancy. One baby was Rs negative, but 13 of the remaining 24 babies survived. Most of the foetal deaths were associated with a rapid rise in antibody level uncontrollable by plasmapheresis and which followed either amniocentesis or intra-uterine transfusion. Plasmapheresis throughout pregnancy with early delivery and avoidance of amniocentesis is recommended.

Amniocentesis↗

PubMed1977

The induction of chromosomal abnormalities by inhalational anaesthetics.

When Vicia faba root tips are exposed for 2 h to clinically useful concentrations of halothane or methoxyflurane in air, or to halothane in 80% nitrous oxide/20% oxygen, there is a transient increase in mitotic index and then abnormal interphase cells are produced in proportion to the anaesthetic concentrations. After exposure there is a period of mitotic inhibition during which the cells become partially synchronised. When colchicine-metaphase cells collected 28 h after exposure are compared with controls and with metaphases collected only 4 h after exposure, they show a significant increase in the incidence of aneuploidy, tetraploidy and the results of chromosome breakage. It is suggested that all the abnormalities seen can be accounted for by the effects of the anaesthetics on spindle movements, and that at the concentrations used the anaesthetics have no mutagenic effects on chromosomes in interphase.

Aneuploidy↗

PubMed1974