The present study was undertaken to determine the role of metabolic disturbance in noise-induced hearing loss by histochemical studies of cytochrome oxidase activity. Adult normal albino guinea pigs were used. The experimental animals were exposed to broad-band noise at 105 dB SPL for 24 h. The control animals were not exposed to the noise. The thresholds of the auditory brainstem response (ABR) of all guinea pigs were measured 3 times: before noise exposure, 1 day and 1 month later. The difference between the ABR thresholds before and after noise exposure was statistically significant. Vibratome sections of decalcified cochleae of the noise-exposed (n = 8) and control groups (n = 4) were incubated with Spector's medium and embedded with Epon. Thin sections (2 microm) and ultrathin sections (100 nm) were cut to observe cytochrome oxidase activity in the stria vascularis under light and electron microscopes, respectively. A decreased activity of cytochrome oxidase was consistently shown in the normal-appearing stria vascularis of most noise-exposed ears. Acoustic trauma has an adverse effect on cytochrome oxidase activity in the stria vascularis as well as on hearing. A decrease in the activity of cytochrome oxidase implicates that metabolic damage may play a role in noise-induced hearing loss.

Animals↗

PubMedDate not supplied

Tone detection in Mandarin-speaking hearing-impaired subjects.

The ability of native Mandarin-speaking, hearing-impaired subjects to detect Mandarin tones was assessed in this study. Nine subjects with mild sensorineural hearing loss (SNHL) and nine subjects with moderate SNHL participated in the study. Nine normal subjects served as control. All subjects received a tone detection test and Chinese word recognition test. The results show that tone detection was only minimally impaired in the mild SNHL group if audibility of the stimulus is well compensated for. In the moderate SNHL group, the mean score was significantly lower, but the difference was small. This suggests that tone detection is only slightly impaired for subjects with moderate hearing loss. For each individual tone, the mean scores for tones 2 and 3 were lowest and most easily confused by all normal and hearing-impaired subjects. No significant correlation was found between the tone detection score and word recognition score for all subjects. The relatively preserved ability to perceive tones in mild and moderate SNHL subjects may be helpful in their speech recognition.

Adolescent↗

PubMedDate not supplied

Mondini dysplasia with recurrent meningitis.

Mondini dysplasia is a congenital malformation of the inner ear, commonly associated with hearing impairment, cerebrospinal fluid otorrhea/rhinorrhea and recurrent meningitis. Two such cases are described, with hearing impairment, cerebrospinal fluid rhinorrhea, and several episodes of meningitis. Diagnosis was confirmed by high-resolution computed tomography. After surgical correction of the malformation, there was no recurrent episode of meningitis at subsequent follow-up. To avoid the suffering and the sequelae of recurrent meningitis, an early diagnosis and prompt surgical intervention are crucial for such patients.

Child↗