Antigen-specific suppressor cell activity in procainamide therapy.
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Aged↗
Biomedical subjects
C J Shamess
Publications and source records attributed to C J Shamess.
Intra-arterial alprostadil for nonatherosclerotic vasculopathy.
A 33-year-old man with a nonatherosclerotic vasculopathy of undetermined origin had progressive occlusive disease of the lower limb vessels. The resultant severe rest pain and ischemic ulceration of his foot were inoperable and unresponsive to conventional drug therapy. Treatment was begun with intra-arterially administered alprostadil (prostaglandin E1), a vasodilator and inhibitor of platelet aggregation. Although immediate benefit was equivocal, his rest pain had disappeared six weeks after infusion, and the ischemic ulcer almost healed completely. Blood flow studies showed increased flow to the feet, consistent with the subjective improvement. The beneficial effect of alprostadil suggests that further studies with this agent are warranted for patients with nonatherosclerotic vasculopathy.
Adult↗
Fulminant colitis complicating gold therapy.
Enterocolitis is lesser known complication of gold therapy. Two cases of fulminant colitis, complicating chrysotherapy for rheumatoid arthritis are described. One patient required colectomy, whereas the other responded to intensive medical treatment. Colonic biopsies demonstrated extensive ulcerations, diffuse edema, multiple hemorrhages and a dense mononuclear cell infiltrate. Our experience emphasizes the paramount importance of early recognition and treatment of this serious complication.
Arthritis, Rheumatoid↗