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Biomedical subjects

C J Simpson

Publications and source records attributed to C J Simpson.

At least 19 recordsLinked to original sources
PubMed1993

Home-based care and standard hospital care for patients with severe mental illness: a randomised controlled trial.

"OBJECTIVE--To compare the efficacy of home based care with standard hospital care in treating serious mental illness. DESIGN--Randomised controlled trial. SETTING--South Southwark, London. PATIENTS--189 patients aged 18-64 living in catchment area. 92 were randomised to home based care (daily living programme) and 97 to standard hospital care. At three months' follow up 68 home care and 60 hospital patients were evaluated. MAIN OUTCOME MEASURES--Use of hospital beds, psychiatric diagnosis, social functioning, patients' and relatives' satisfaction, and activity of daily living programme staff. RESULTS--Home care reduced hospital stay by 80% (median stay 6 days in home care group, 53 days in hospital group) and did not increase the number of admissions compared with hospital care. On clinical and social outcome there was a non-significant trend in favour of home care, but both groups showed big improvements. On the global adjustment scale home care patients improved by 26.8 points and the hospital group by 21.6 points (difference 5.2; 95% confidence interval--1.5 to 12). Other rating scales showed similar trends. Home care patients required a wide range of support in areas such as housing, finance, and work. Only three patients dropped out from the programme. CONCLUSIONS--Home based care may offer some slight advantages over hospital based care for patients with serious mental illness and their relatives. The care is intensive, but the low drop out rate suggests appreciation. Changes to traditional training for mental health workers are required."

Activities of Daily Living↗
PubMed1991

Isolation and sequence of a cDNA encoding human platelet phosphofructokinase.

A cDNA encoding human platelet 6-phosphofructokinase (PFK; EC 2.7.1.11) has been isolated from a human lymphocyte Raji cell line cDNA library using a cDNA for human muscle PFK as a probe. The platelet cDNA contains 900bp of carboxy terminal coding sequence and 238bp of downstream untranslated region. The deduced amino acid sequence shows 71% identity to the amino acid sequence for the human muscle isoenzyme and 63% identity to the human liver isoenzyme. Almost all of the amino acid residues contributing to catalytic and effector sites in the three isoenzymes are conserved. The platelet gene has been assigned to chromosome 10p15.2-p15.3 by using the cDNA clone as a biotinylated probe against human chromosome spreads (Morrison et al. 1991, submitted to Human Genetics).

Amino Acid Sequence↗
PubMed1990

Binding of zinc and calcium to inositol phosphates (phytate) in vitro.

Inositol compounds with three to five phosphate groups (IP3-IP5) were produced by hydrolysis of phytate (inositol hexaphosphate, IP6) and their binding affinities for calcium and zinc investigated at neutral pH with relative concentrations that had been found in a range of students' meals. Zn solubility was negligible at many of these concentrations, with less Zn bound to precipitates of Ca-IP6 than Ca-IP5. The capacity to precipitate Zn at these ratios fell between IP5 and IP3. Zn was partially desorbed by soluble chelators (histidine and picolinate), especially when it had been adsorbed to preformed Ca-IP precipitates. A lower proportion of Zn was accessible to soluble chelators from Ca-IP4 than the other compounds. IP3-IP4 were hydrolysed by phytase more readily than IP5-IP6.

Calcium↗
PubMed1989

The chronically mentally ill in community facilities. A study of quality of life.

The quality of life of chronically mentally ill patients in acute wards in a district general hospital, a hostel ward and group homes was compared. Within the spectrum of care of these patients, the severity of psychopathology corresponded to their placement. Analysis, including adjustments for the influence of psychopathology, showed differences between the three types of facility. Although differences existed between all types of care, residents in group homes and the hostel ward shared more similarities in quality of life than those in the district general hospital. Problems of caring for the chronically mentally ill on acute wards are highlighted.

Adult↗
PubMed1987

Effect of cimetidine on prognosis after simple closure of perforated duodenal ulcer.

A prospective controlled study in 60 patients undergoing simple closure of perforated duodenal ulcer demonstrated a significant (P less than 0.05) benefit following postoperative cimetidine treatment, in terms of avoiding subsequent dyspeptic symptoms and complications of peptic ulcer disease. Thus cimetidine is recommended in the follow-up management of perforated duodenal ulcers.

Aged↗
PubMed1987

The relationship between pre-operative anxiety and post-operative delirium.

Forty five elderly patients undergoing total hip replacements were assessed one day before and two days after surgery in order to explore the relationship between pre-operative anxiety and post-operative delirium. Anxiety was measured by the State-Trait Anxiety Inventory and delirium was measured by a decrease in various measures of cognitive functioning. No relationship was found and this is discussed in the light of two theories which would have predicted one. Other secondary findings are reported and discussed.

Aged↗
PubMed1987

Pre-operative intravenous cholangiography as an alternative to routine operative cholangiography in elective cholecystectomy.

Pre-operative intravenous cholangiography as an alternative to routine operative cholangiography at elective cholecystectomy has been assessed in a retrospective manner in 286 patients. Most of the examinations were technically satisfactory (94.7%) and of these 1.8% proved incorrect. A small number of patients developed transient skin rashes (1.3%), the only side effect recorded. Preoperative intravenous cholangiography offers an alternative to routine operative cholangiography with the potential saving of both operating staff and radiologists' time, without sacrificing accuracy.

Adolescent↗
PubMed1987

Electrodermal response as a monitor in electroconvulsive therapy.

A study comparing the use of electrodermal response with the cuff technique and clinical judgment as monitors in electroconvulsive therapy is reported. A sensitivity of 90.5% and a specificity of 41.7% were found and it is, therefore, suggested that this method is not used routinely.

Electroconvulsive Therapy↗
PubMed1985

Meckel's diverticula in an adult surgical unit eleven years experience.

A retrospective review of Meckel's diverticula over an 11-year period in a surgical unit, to which children were seldom admitted, revealed 28 diverticula, seven of which were symptomatic from inflammatory disease or obstruction. There was no morbidity nor mortality in this group. Twenty-one diverticula were removed as incidental findings, four patients dying from the cause of their symptoms. The complications of Meckel's diverticulum can be satisfactorily managed and are uncommon in the adult. Prophylactic diverticulectomy is difficult to justify.

Adolescent↗
PubMed1984

Doctors and nurses use of the word confused.

A questionnaire was sent to 274 doctors and nurses. The first section was to see if certain symptoms and signs elicited the description of patients as 'confused', and the second to discover the respondents' definitions. The results showed a marked discordance in health workers' understanding of this word 'confused' in reference to patients, and it is suggested that it should only be used if it is clearly defined.

Cognition Disorders↗