Inheritance of an anomalous Pi marker in horses.
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Biomedical subjects
C J Stormont
Publications and source records attributed to C J Stormont.
Associations between genetic markers and growth and carcass traits in a paternal half-sib family of Angus cattle.
Segregation of polymorphic marker genes in a paternal half-sib family of Angus cattle was used to detect associations between genetic markers and quantitative traits. The half-sib family selected (n = 146) had a sire that was heterozygous at six polymorphic marker loci; BoLA-A (class I major histocompatibility complex), B, C and F blood group systems, serum transferrin and vitamin D binding protein. Segregation of alleles fit the expected ratios for all marker loci. Performance data analyzed for all half-sibs included birth, 205-d and 365-d adjusted weights and pre- and post-weaning average daily gains. Carcass data for steers (n = 61) included carcass weight, rib-eye area, 12th rib fat thickness, percent kidney, heart and pelvic fat and yield grade. Least squares means were compared for differences in performance and carcass traits between groups of half-sibs that inherited alternative paternal alleles. Significant effects were found for two of the six marker systems. Half-sibs that inherited the chromosomal segment (CS) marked by the RBC-B system BGKOxY2A'O' phenogroup had heavier 205-d (9.1 kg) and 365-d (17.3 kg) adjusted weights, faster preweaning average daily gains (.04 kg) and less fat thickness (-2.6 mm) than sibs that inherited the CS marked by I2Y2E'1Y'. Also, sibs that inherited the CS marked by the BoLA-w2 allele had larger rib-eye areas (4.1 cm2) than sibs that inherited BoLA-w28. These data indicate the probable presence of genes linked to the RBC-B and BoLA systems that affect preweaning growth and lean muscle content.
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Blood groups in animals.
The membrane of RBC is literally peppered with a great variety of antigenic determinants (blood factors). Some are fixed genetically, ie, they occur on the RBC of all members of the species under study. Others segregate genetically, ie, they occur on the RBC of some but not all members of the species under study. It is these segregrating determinants that form the blood groups proper, the classic example being blood factors A and B of the ABO system of human blood groups. The number of blood group determinants varies considerably between species (eg, greater than 80 in domestic cattle to only 1 in the new world Camelidae). Genetic analysis has shown that the blood factors belong to one or another of a limited number of blood group systems. Some of these systems, similar to the B system of cattle, are enormously complex, whereas others involve but a single blood factor. The object of the present paper is to report on the extent of genetic variation in blood groups and how information on blood groups is being used clinically.
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