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C J de Blaey

Publications and source records attributed to C J de Blaey.

14 recordsLinked to original sources
PubMed1984

Non-enhancement of sodium cromoglycate intestinal absorption by quaternary ammonium ions. An effect of salt on ion-pair formation?

Studies on the nature of rat small intestine perfusates indicate that this environment is thermodynamically unfavourable for the production of ion pairs between cromoglycate and alkylbenzyldimethylammonium ions. This is suggested as being the reason why, unlike previously found for ocular absorption of cromoglycate, these quaternary ammonium ions do not alter cromoglycate intestinal absorption.

Animals↗
PubMed1977

Dissolution kinetics of soluble nondisintegrating disks.

An equation describing the isotropical dissolution of soluble nondisintegrating disks was developed. It was equivalent to the cube root law only if the height and diameter of the disk were equal. The dissolution kinetics of sodium chloride disks were examined, using a beaker equipped with a centrifugal stirrer as the dissolution chamber. The fit of the experimental data to the cube root law had a coefficient of variation of about 4-5%. It was demonstrated statistically that a fit to a square root of mass versus time relation was significantly better. With increasing porosity, the dissolution process proceeded faster than predicted on the basis of the diffusion-convection model. An explanation is proposed by assuming an increased effective dissolution surface.

Densitometry↗
PubMed1971

[Mixture problems].

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Chemistry, Pharmaceutical↗