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C J van Duin

Publications and source records attributed to C J van Duin.

6 recordsLinked to original sources
PubMed1997

[Pseudomyxoma peritonei].

Pseudomyxoma peritonei was diagnosed in 3 men aged 38, 66 and 54 years with weight loss and distension of the abdomen. Pseudomyxoma peritonei results from seeding of the peritoneal cavity with mucus-producing epithelium. The disease is traditionally characterized by accumulation of huge amounts of mucinous ascites, relatively long survival and absence of distant, extraperitoneal metastases. Mostly, the primary tumour is an appendicular adenoma or adenocarcinoma. Sometimes, the primary tumor is localized in the ovaries. Extensive surgical debulking with postoperative intraperitoneal chemotherapy appears to be the treatment of choice.

Adult↗
PubMed1994

Clinical significance of intranodal and extranodal growth in lymph node metastases of non-small cell lung cancer.

In non-small cell lung cancer with mediastinal lymph node metastasis, intranodal growth is regarded as prognostically more favourable than extranodal growth. We evaluated the clinical implications. Mediastinal lymph node metastases removed at mediastinoscopy and/or surgery were classified as intranodal, extranodal or indefinite. "Minimal N2 disease" denoted a solitary, intranodal metastasis, "extranodal" at least one extranodal lymph node metastasis, and "indefinite" more than one intranodal or at least one indefinite metastasis. Although in patients with resected N2 disease, c. 21% of the nodal metastases were "indefinite", survival was significantly better in minimal N2 disease than in the combined groups with extranodal and indefinite lymph node metastases. Of the metastatic nodes removed at mediastinoscopy, 75% were unsuitable for definite classification as only intranodal or extranodal. Only 1 of 49 patients had purely intranodal N2 disease. Thus, it was seldom feasible to classify mediastinoscopic lymph node involvement as intranodal or extranodal, and this classification is unhelpful as regards decisions on thoracotomy. However, when nodal involvement in resected N2 disease was limited to a single node with intranodal growth, the prognosis was better than in patients with extranodal disease or more than one intranodal metastasis or indefinite nodes.

Carcinoma, Non-Small-Cell Lung↗
PubMed1993

Mediastinal lymph node dissection in resected lung cancer: morbidity and accuracy of staging.

A study was performed to investigate the morbidity of mediastinal lymph node dissection (MND) and to establish its contribution to the accuracy of staging in surgically treated non-small cell lung cancer. Between 1988 and the middle of 1991 a systematic sampling of mediastinal lymph nodes was done in 20 patients and a MND was carried out in 65 patients. Data from these patients were compared with those from a control group of 70 patients operated on in 1986 and 1987, who would have had MND if they had been treated in the years after 1988. The groups were comparable according to important clinical characteristics. There was a significantly greater fluid production via the drains in the groups with systematic sampling and MND, compared with the controls. Volume of blood lost during the operation and number of units blood transfused perioperatively were not significantly different between the groups. Three lesions of the recurrent laryngeal nerve and two episodes of chylothorax were observed, all probably caused by MND. The discovery ratio for N2 disease in the MND and systematic sampling groups together compared with the control group was 2.1, with a 95% confidence interval from 1.04 to 4.2.

Adenocarcinoma↗
PubMed1991

Accuracy of computed tomography of the mediastinum in bronchogenic carcinoma.

The results of preoperative CT-scanning were compared with the pathological findings in lymph-nodes taken at mediastinoscopy and/or thoracotomy in 144 patients to determine the accuracy of CT of the mediastinum in staging lung cancer. Ninety-nine patients had squamous cell carcinoma, 31 adenocarcinoma, nine undifferentiated large-cell carcinoma and five patients had carcinoma of a mixed cellular type. Mediastinoscopy was done in 105 patients and thoracotomy in 126. The results of our study showed that CT is useful to select patients for mediastinoscopy for T1 lung cancer in general because of a negative predictive value of 98 per cent. CT is also useful for T2 and T3 lung cancer located at the left lower lobe or the right upper, middle or lower lobe (negative predictive value 87%). However, mediastinoscopy is always necessary in patients with T2 or T3 lung cancer at a main bronchus or a left upper lobe because of the low negative predictive value (58%). Preoperative aorto-pulmonary window evaluation is not recommended in case the CT-scan for the aortopulmonary window is negative because of a reasonable negative predictive value (81%).

Carcinoma, Bronchogenic↗