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Biomedical subjects

C J van Gelderen

Publications and source records attributed to C J van Gelderen.

10 recordsLinked to original sources
PubMed1993

Polycystic ovarian syndrome. Evidence for an autoimmune mechanism in some cases.

Antiovarian autoantibodies localized to the granulosa cells were detected in 50% of a group of eight patients diagnosed with polycystic ovarian syndrome. An analogy is drawn to other endocrinopathies characterized by hypersecretion of hormones, notably thyroid and adrenal, and a pathogenetic mechanism involving stimulating antibody is postulated.

Adult↗
PubMed1987

Meconium during labour--self-medication and other associations.

Prior to artificial rupture of membranes, 498 women were questioned about obstetric and social factors including self-medication during pregnancy. Caesarean section (P less than 0,01) and low Apgar scores (P less than 0,001) were significantly more common in pregnancies complicated by fetal meconium passage. Meconium passage was more common in women who had recently taken castor oil (P less than 0,01) and possibly herbal substances called 'sihlambezo' (trend P less than 0,2). Use of laxatives or enemas and other obstetric risk factors were not associated with meconium passage.

Castor Oil↗
PubMed1987

Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium.

The content of cytoplasmic 17 beta oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium (P = 0.0002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.

Adult↗
PubMed1986

Labour in patients with a caesarean section scar. The place of oxytocin augmentation.

Fifty-two patients who had had a single previous caesarean section were submitted to a trial of scar. Labour was monitored by internal tocography and direct fetal heart rate monitoring. Oxytocin infusion was employed when uterine work proved to be inadequate. The oxytocin-augmented and unstimulated groups were compared. Oxytocin augmentation improved uterine work and did not result in significant fetal or maternal morbidity or mortality. Internal tocography was found to be of value, but fetal heart rate monitoring was essential.

Asphyxia Neonatorum↗
PubMed1986

Pregnancy complicated by maternal hydrocephalus. A report of 3 cases.

The obstetric management of 3 women with stable hydrocephalus is presented. The few obstetric complications were unrelated to the maternal hydrocephalus, and specific management of the maternal condition was not necessary. Better management of hydrocephalus in infancy, as well as of the other forms of non-tumoral hydrocephalus, has led to more adults in a stable state with the condition and pregnancy will occur in some of these. A plea is made for all female patients with hydrocephalus to have a ventriculoperitoneal shunt rather than a ventriculoatrial one, with a view to reduction of complications in later pregnancies.

Adolescent↗
PubMed1980

'One-visit' therapy for pelvic inflammatory disease.

Acute pelvic inflammatory disease is a very common gynaecological disorder, and more often than not it is caused by a mixed infection of aerobic and anaerobic organisms. Routine bacteriological investigation is consequently of little practical value in determining the therapeutic approach. In an open comparative trial, 60 patients were divided into two treatment groups of 30 patients each. Both groups received a combination of penicillins, probenecid, a sulphonamide and an imidazole derivative active against protozoa and anaerobes. Both regimens resulted in virtually the same therapeutic response in patients hospitalized for 6 days. The regimen consisting of ornidazole (as opposed to metronidazole) and the ultralong-acting sulphonamide, sulphadoxine (as opposed to sulphadimidine), can be given in a once-only administration, thereby greatly reducing the possibility of non-compliance in patients treated, as is customary, on an outpatient basis.

Acute Disease↗
PubMed1978

Maternal intensive care.

The evolution of a maternal intensive care unit (ICU) is described and the management of the patients treated over a 10-month period is outlined. The principles, practice and methods of intensive care for the parturient are discussed.

Female↗