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Biomedical subjects

C Juul

Publications and source records attributed to C Juul.

9 recordsLinked to original sources
PubMed1998

Prognostic accuracy of the mean of the largest nucleoli, vascular patterns, and PC-10 in posterior uveal melanoma.

OBJECTIVE: This study aimed to compare the prognostic value and the predictive accuracy of the PC-10 cell cycling marker with the largest tumor diameter, the mean of the largest nucleoli, and vascular patterns in posterior uveal melanoma. DESIGN: The study design was a case-control study. PARTICIPANTS: Eyes enucleated for posterior uveal melanoma from patients who either died of metastatic melanoma or survived without signs of metastatic disease 10 years or more after surgery were studied. INTERVENTION: Three observers assessed the above prognostic indicators and standard histopathologic characteristics from microslides without access to survival data. MAIN OUTCOME MEASURES: Univariate and multivariate Cox models for survival were constructed, and a multiparameter prognostic index was calculated for each patient, based on covariates obtained from the final Cox model. The prognostic accuracy was determined by receiver operating characteristic curve analysis. RESULTS: The log PC-10 count, vascular networks, mean of the largest nucleoli, largest tumor diameter, age of patient, and prognostic index were independently associated with outcome. However, each of these indicators had no more than a poor-to-moderate predictive accuracy, and only the prognostic index was significantly better than the largest tumor diameter. CONCLUSIONS: The PC-10 count retains a prognostic value in uveal melanoma when adjusting for the effect of the mean of the largest nucleoli and diverse vascular patterns. A prognostic index combining two or more indicators may improve the predictive precision.

Adult↗
PubMed1995

[Menstrual cycle and surgery of breast cancer. Point of time for the surgery of primary breast cancer in connection with menstrual cycle is without prognostic significance].

From 1977 to 1989 6488 patients under fifty years with primary breast cancer were registered in the nationwide Danish Breast Cancer Cooperative Group (DBCG). Among these information on last menstrual period prior to surgery was available in 1635 cases which constitute the study group of the present analysis. The group was representative of the total group with regard to prognostic factors and survival. In the study group time of surgery in relation to last menstrual period was found to have no influence on five- and ten year survival.

Adult↗
PubMed1994

Timing of surgery in relation to menstrual cycle does not predict the prognosis in primary breast cancer. Danish Breast Cancer Cooperative Group.

From 1977 to 1989 6488 patients under 50 years with primary breast cancer were registered in the nationwide Danish Breast Cancer Cooperative Group (DBCG). Among these, information on last menstrual period prior to surgery was available in 1635 cases which constitute the study group of the present analysis. The group was representative of all women operated upon during the period with regard to prognostic factors and survival. In the study group time of surgery in relation to last menstrual period was found to have no influence on 5 and 10 years survival.

Adult↗
PubMed1989

[Complications of appendectomy during pregnancy].

A retrospective investigation revealed that in 11 out of 23 pregnant women submitted to operation on account of suspected appendicitis the diagnosis could be confirmed. The perinatal and the maternal mortalities were both 0. In the women submitted to operation, the frequency of obstetric complications was found to be 17%, 95% confidence limits 5-39%, and the frequency of surgical complications was 17%, 95% confidence limits 5-39%. The diagnostic specificity was found to be significantly higher in women who had previously born children. Brief duration of symptoms preoperatively and operation employing beta-sympathomimetics are recommended.

Adult↗
PubMed1987

Intravesical pressure changes during bladder drainage in patients with acute urinary retention.

Using a transurethral approach intravesical pressure and blood pressure were recorded in 10 males with acute urinary retention during either continuous or fractionated drainage. Upon evacuation of the initial 100 cm3 urine the intravesical pressure declined to approximately 50% of the initial value in both groups relieving pain in all patients. Blood pressure was significantly lowered following the procedure, but clinical manifestations were absent. One patient demonstrated hematuria, but treatment was not necessary. The study renders no support for previous recommendations of fractionated outlet of urine in this condition.

Acute Disease↗
PubMed1982

The effect of prostatectomy on upper urinary tract function.

59 patients with obstructive prostatic hypertrophy (BPH) were evaluated regarding the influence of prostatectomy on upper urinary tract function by means of [51Cr]EDTA clearance and gamma camera renography measurements. 25 patients were randomly allocated to transvesical and 34 patients to transurethral prostatectomy. At the 6-month follow-up a slight decrease in glomerular filtration rate (GFR) was seen in the total patient group. Residual renal activity 20 min following injection (A20) as well as half-peak time values showed upper urinary tract obstruction in 54% of the patients preoperatively, whereas dilatation of the upper urinary tract was demonstrated at i.v. pyelography in only 15%. Patients with renographic obstruction preoperatively had low GFR values compared with patients without obstruction. In patients with upper urinary tract obstruction, prostatectomy relieved the obstruction, even in the case of normal urography. In patients with normal upper urinary tract, a clinically insignificant decrease in GFR and increase in A20 and half-peak time was observed. No differences with regard to upper urinary tract function were seen on comparing transurethral with transvesical prostatectomy.

Aged↗
PubMed1981

Locally induced digital vasospasm detected by delayed rewarming in Raynaud's phenomenon of occupational origin.

The rewarming time of fingers after hand cooling to 10 degrees during ischaemia was significantly prolonged in all subjects with Raynaud's phenomenon of occupational origin compared with normal reaction and patients with primary Raynaud's phenomenon. The temperature is faster and easier to record than pressure or pulse volume. Population studies are in progress with the described technique.

Adolescent↗