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Biomedical subjects

C K Atal

Publications and source records attributed to C K Atal.

At least 37 records · Page 2Linked to original sources

Ethno-medico-botanical investigations in Kerala I. Some primitive tribals of western ghats and their herbal medicine.

Ethno-medico-botanical investigations of seven primitive tribals, Cholanaikken, Pathinaikken, Paniyan, Kuruman, Irular, Adiyan and Kurichan, living in the densely forested high-lands of western ghats in Kerala were carried out. One of the tribes, Cholanaikken, is the most primitive tribe known in the Indian subcontinent. Ethnically they appear close to the Australian aboriginals. All other tribes of Kerala have mixed features of Veddoids, Negroids, Australian aboriginals and Dravidian races suggesting the mixing of these races at various periods of Kerala's historical past. All the tribals investigated practice their own traditional system of medicine. The medical treatment of diseases of most of these tribals involves mysticism, magical incantations, sacrificial practices and divining. They also utilize a wide variety of herbs in treating the physical symptoms. These medicinal herbs were collected, identified and some of the interesting plants for which new medicinal uses were claimed by the tribals are described here.

Humans↗

Clinical evaluation of a new antilithiatic drug, "Debelysin".

"Debelysin", a new antinephrolithiatic drug, was administered in 5-ml oral doses, 3 times daily: to 30 nephrolithiatic patients for 6 months, and to 30 patients with surgically removed renal calculi for 12 months. "Debelysin" showed diuretic action which affected neither the electrolyte nor the acid-alkaline balance. The majority of patients responded to "Debelysin" with a decrease in diurnal calciuria and phosphaturia. During the treatment the calculi did not increase in size and the recurrence of the lithiasis was not observed. No toxic and clinical side effects of "Debelysin" were noted.

Adult↗

Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.

Experiments were conducted to evaluate the scientific basis of the use of the trikatu group of acrids (long pepper, black pepper and ginger) in the large number of prescriptions in Ayurveda. [3H] vasicine and [3H] sparteine were taken as test drugs. Piper longum (long pepper) increased the blood levels of vasicine by nearly 233%. Under the influence of piperine, the active principle of Piper species, sparteine blood levels increased more than 100%. The results suggest that these acrids have the capacity to increase the bioavailability of certain drugs. It appears that the trikatu group of drugs increase bioavailability either by promoting rapid absorption from the gastrointestinal tract, or by protecting the drug from being metabolised/oxidised in its first passage through the liver after being absorbed, or by a combination of these two mechanisms.

Abortifacient Agents↗

Absorption, distribution and excretion of N-4-phenyl-phenacyl-heliotridanium bromide.

Absorption, distribution and excretion of a tritium labelled halogenomethyl-aryl-ketone derivative of pyrrolizidine alkaloid heliotridine is studied. This compound, i.e., N-4-phenylphenacyl heliotridanium bromide, a potent non-specific antispasmodic shows maximum blood level at 10 min after an i.m. injection. Half-life in blood is 1.5 h. Gastrointestinal tract (GIT) shows maximum incorporation of activity and displays main pharmacological activity. Highest concentration of drug is noticed in liver by 20 min showing a sharp fall thereafter. Excretion is mainly through urine.

Animals↗