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C K Kalogeropoulos

Publications and source records attributed to C K Kalogeropoulos.

2 recordsLinked to original sources

Radiation of anginal pain to the legs.

Pain radiated from the chest to one or both legs (17 cases), or from the legs to the chest (two cases) in 19 patients with angina or acute myocardial infarction. The leg pain was assumed to be related to the angina pectoris when both were of a similar character and occurred together, when the leg pain occurred at rest, and when there were normal peripheral pulses in the leg. Pain was felt in the left leg by 10 patients, the right leg by two patients, and in both legs by seven. Three patients experienced pain in the thigh(s), six in the shin(s), and 10 had pain in both. In six patients the pain extended down to the inner two to four toes. The pain was always felt in front of the legs. This distribution accords with the suggestion that some sensory cardiac nerve fibres occur in the lumbar sympathetic ganglia and that pain is projected into the corresponding dermatomes.

Adult

Limitation of infarct size by decrease of afterload with prazosin.

To investigate the possibility of limiting infarct size by decreasing afterload 32 normotensive patients with uncomplicated acute myocardial infarction (AMI) were put on prazosin and compared with 32 control patients. Blood pressure fell significantly lower in the prazosin group without increase of heart rate. The mean daily and peak levels of serum aspartate transaminase and lactic dehydrogenase and the calculated from the 12 lead ECG mean daily sum of ST segment elevation, number of leads with ST greater than or equal to 0.1 mV, mean ST elevation, number of new Q waves greater than or equal to 0.03 s and the loss of height of R waves were significantly less in the prazosin group. ST segment re-elevation occurring on 2nd-3rd day in the control group was absent or minimal in the prazosin group. The enzyme levels and the change of the ECG variables correlated fairly well with the change of blood pressure. These findings indicate that, at least in the selectively good risk cases of our material, reduction of afterload without increase of heart rate induced by prazosin may favorably influence the balance of myocardial oxygen supply and demand early in AMI and prevent death of jeopardized ischaemic tissue, thus limiting the final extent of the infarct.

Adult