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Biomedical subjects

C K Leong

Publications and source records attributed to C K Leong.

5 recordsLinked to original sources

The locus of so-called IQ test results in reading disabilities.

It would appear the question of relevance of IQ in the assessment and remediation of children with RD is not quite the relevant question to ask, if only traditional intelligence tests are the focus. From the psychoeducational point of view of refining diagnosis, and from the administrative perspective of accountability, it would be helpful to accept a threshold of something like an IQ of 85 as the lower bound in defining learning or reading disabilities. A discrepancy from this threshold as derived from regression analysis or other more refined analyses and taking into account varying reliabilities, intercorrelations, and standard errors of measurement of different measuring instruments may constitute a learning or reading disability. How discrepant the aptitude-achievement should be to constitute a "significant" difference is a function of, among other factors, the material and human resources available to any particular school system. Leong (1987) has made suggestions for essentially a two-stage assessment leading to more refined diagnosis with the use of well-standardized group tests and teachers' estimates for the first stage (assessment) and more refined individual tests to diagnose those showing discrepant aptitude-learning performance in the border-zone. The rationale is that all those children requiring special services are so served and those in the uncertainty region must be carefully diagnosed so as to minimize so-called "misfits" in accordance with signal detection principles. It should be noted that the diagnosis of learning or reading disabilities can never be exact, even with the use of reliable and valid test instruments, and the "fuzzy set" approach should apply to the process (Horvath, Kass, & Ferrell, 1980).(ABSTRACT TRUNCATED AT 250 WORDS)

Achievement

Differential cerebral involvement in perceiving Chinese characters: levels of processing approach.

Three experiments were designed to determine the accuracy and latency with which right-handed Chinese university students (12 females and 12 males) recognized Chinese characters in the left and right visual half-fields (VHFs). The experiments varied in the "depth" of processing required. Experiment 1 was a lexical decision task in which the configuration of the stimulus (a real Chinese character or the mirror image of a real character) determined whether the grapheme was an actual character. Experiment 2 required phonological processing; i.e., subjects had to decide whether a character (or a foil) matched the sound of an orally presented Chinese character. Experiment 3 required semantic processing; i.e., subjects had to decide if a character (or a foil) belonged to a particular semantic category. In each experiment, single characters were presented unilaterally for 150 msec. There was a significant right VHF superiority for accuracy scores for Experiments 2 and 3 but not for Experiment 1. None of the experiments yielded significant visual asymmetries in reaction time. The results do not support previous claims of orthography-specific laterality, but instead show that laterality effects for morphemic stimuli vary with the orthographic, phonological, and semantic processing demands of the task.

Adult

Effect of adenine nucleotides on NAD-dependent isocitrate dehydrogenases in rhizobia and bacteroids of legume root nodules.

ATP, ADP, AMP and cyclic AMP inhibit NAD-dependent isocitrate dehydrogenase (L-s-isocitrate : NAD-+ oxidoreductase, EC 1.1.1.41) from rhizobia but have no effect on the enzyme from corresponding bacteroids. This was observed using three rhizobial strains two of which are effective, and one ineffective, with Lotus pedunculatus. Using partially purified enzyme from each of the three rhizobial strains it was found that the adenine nucleotides inhibit the enzyme by competing with NAD-+, not with isocritrate. The rate of reaction catalysed by the enzyme (expressed as activity per mg protein) in cell-free extracts of each of the effective rhizobial strains was about three times that of the reaction in extracts of the corresponding bacteroids. No correlation was found between effectiveness and NAD-dependent isocitrate dehydrogenase activity in the rhizobial cells.

Adenine Nucleotides