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C K Partington

Publications and source records attributed to C K Partington.

6 recordsLinked to original sources
PubMed1991

Quantitative determination of acid-labile DNA in cervical intraepithelial neoplasia.

Using a modified Feulgen hydrolysis procedure and integrating microdensitometry, the acid-labile nuclear DNA in exfoliated cervical epithelial cells was quantified in a range of histologically confirmed cervical intraepithelial neoplasia (CIN), invasive cancer, and normal controls. The mean relative optical densities obtained for each sample group showed an increase from normal epithelium, through CIN grades, to invasive cancer. Although there was some overlap between groups, the difference in the overall mean values between the adjacent groups was statistically significant. The sensitivity of the test was 87.1% with a specificity of 99.2% and a predictive value of 99.5%, with no false negatives in the severe dysplasia and cancer groups. Quantitative data allows the threshold value to be altered to vary the sensitivity and specificity according to prevailing requirements. This suggests the possibility of using quantitative acid-labile DNA measurements to improve existing screening for cervical precancer.

Cell Nucleus↗
PubMed1989

Laser vaporization versus laser excision conization in the treatment of cervical intraepithelial neoplasia.

One hundred patients with histologically confirmed cervical intraepithelial neoplasia suitable for ablative therapy were randomly allocated to treatment by either laser vaporization or laser excision conization under local anesthesia in the outpatient colposcopy clinic. The two methods were compared with respect to the immediate surgical complications, ease of performance, and long-term complications. They were comparable in most respects, and both were well accepted by the patients. Laser excision had the added advantage of providing further material for histologic examination to confirm the absence of invasion and the completeness of excision of the lesion.

Adolescent↗
PubMedDate not supplied

Should smears in a colposcopy clinic be taken after the application of acetic acid?

Conventionally, cervical smears obtained during a colposcopic examination are taken before the application of acetic acid. However, this occasionally precipitates bleeding and removes epithelium from the cervix, particularly in the presence of cervical pathology, making colposcopic evaluation difficult. This study examined the possibility of deferring the smear until the end of the colposcopic examination. In the first part of the study, the cytologic results on cervical samples taken from the same patient before and after the application of acetic acid were compared. In the second part of the study, only one smear was taken per patient (either before or after colposcopic assessment) to eliminate the possibility that the taking of the first smear affected the quality of the second. The results of both parts of the study showed that deferring the smear until after the application of acetic acid leads to an unacceptably high rate of unsatisfactory and falsely negative smears. Thus, deferring the taking of the cervical smear until after the colposcopic evaluation results in a poor cytologic evaluation, although it might facilitate the colposcopic examination in some patients.

Acetates↗