Induction of rat liver microsomal enzymes by cycloheximide.
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Biomedical subjects
Publications and source records attributed to C K Pushpendran.
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The incorporation of -14C FROM [1-14C]palmitate into blood glucose and liver and kidney glycogen in postnatal mice has been studied. Incorporation of -14C FROM [1-14C]palmitate into blood glucose and hepatic glycogen is relatively high in suck ling mice. Incontrast, the incorporation into kidney glycogen is low in suckling mice and high in adults. The study indicates the possible utilization of palmitate for glucose synthesis.
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Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unlike that of rough and smooth microsomes which shows changes throughout the same period. Activities of cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase increase during the period of maturation and decline during senescence. The decrease during senescence is at different rates in the two microsomal fractions. Microsomal glucose-6-phosphatase, but not adenosine triphosphatase, shows a similar increase during development and decrease during senescence.