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Biomedical subjects

C K Yong

Publications and source records attributed to C K Yong.

9 recordsLinked to original sources
PubMed2005

Mid-term results of tibial plateau fractures.

We studied the factors influencing the mid-term outcomes of tibial plateau fractures treated conservatively (n=21) and surgically (n=27) from December 1994 to December 1997. Joint stability was an important prognostic determinant. In the surgical group, the most important factor was good anatomical reduction. Functional outcomes were comparable between the conservative and surgical groups. We concluded that conservative treatment is a valid option for fractures with minimal displacement and surgical treatment is justified for severely displaced or depressed fractures. Attention must be paid to the recognition and restoration of joint stability and articular surface congruency for a satisfactory outcome.

Adolescent↗
PubMed2000

An unusual presentation of doxycycline-induced photosensitivity.

Photoonycholysis in association with a generalized phototoxic reaction or as an isolated event is a well-recognized complication of the tetracycline group of antibiotics. We describe a 14-year-old white girl with cystic fibrosis who developed photoonycholysis of all 20 nails while receiving treatment with doxycycline. Pediatricians who prescribe tetracyclines should be aware of this potential complication.

Adolescent↗
PubMed1998

Successful use of cyclosporine A in the treatment of refractory thrombotic thrombocytopenic purpura.

Thrombotic thrombocytopenic purpura (TTP) is, in most cases, treatable with plasma exchange therapy (PLEX). Rarely, patients do not respond to PLEX or develop refractory disease despite an initial remission. In these cases, treatment options are limited and the response to established alternative therapies is often disappointing. We report the case of a paediatric patient with TTP who developed refractory disease after an initial response to PLEX. She was subsequently treated with cyclosporine A and showed an immediate and sustained response. CSA may be a safe and effective therapy for patients with refractory TTP and should be studied in randomized, prospective clinical trials.

Adolescent↗
PubMed1990

Large bowel cancer in the young adult.

Within a month, we saw two young national servicemen with adenocarcinoma of the caecum. Both presented to use as emergencies and both had a right hemicolectomy performed. This literature review is to promote a greater awareness of the potential for colorectal cancer in young adults less than 40 years of age. The incidence ranged from 2% to 16.8% of all cases of large bowel cancer. About two-thirds of the tumours were Dukes' C and D at the time of presentation. There was a preponderance of poorly differentiated carcinoma and the mucinous type of carcinoma. Early diagnosis and attempts at curative resection are of utmost importance. Radical extirpation of advanced primary disease is well worthwhile and can be associated with long term survival in the young. Family history is important to identify a group of patients with cancer family syndrome.

Adenocarcinoma↗
PubMed1987

Influence of chronic dietary acid on renal tubular handling of magnesium.

Micropuncture and clearance studies were performed on rats with chronic metabolic acidosis to evaluate the segmental handling of magnesium. Fractional magnesium excretion was 12.6 +/- 2.3% in acidemic rats (blood pH 7.17 + 0.2) compared to 5.1 +/- 1.3% of normal animals (blood pH 7.36 +/- 0.05). Ultrafiltrable magnesium concentrations were similar in both normal and acidotic animals, 0.51 +/- 0.02 and 0.48 +/- 0.03 mM, respectively. Elevation of urinary magnesium excretion was due to diminished reabsorption in the loop of Henle and segments beyond the distal sampling site. Acute correction of the systemic acidosis with NaHCO3 infusions partially corrected the renal magnesium levels as fractional magnesium excretion fell from 12.6% to 3.1 + 0.75%. This was associated with enhanced reabsorption of magnesium in the loop. To determine if acidosis may compromise the renal conservation of magnesium, acidotic rats were subsequently placed on magnesium-restricted diets. Normal and acidotic animals adapted appropriately and to a similar extent when challenged by short-term magnesium-restricted diets. Accordingly, elevation of dietary acid intake and systemic acidosis leads to renal magnesium wasting which is due in part to diminished reabsorption in the loop of Henle. However, chronic acidosis does not compromise the renal adaptive response to dietary magnesium restriction.

Acidosis↗