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Biomedical subjects

C König

Publications and source records attributed to C König.

53 records · Page 3Linked to original sources
PubMed1992

[Acute intermittent porphyria in pregnancy: glucose or hematin therapy?].

The symptoms and management of acute intermittent porphyria (AIP) during pregnancy and delivery are presented on the basis of three case reports. Two patients became asymptomatic after infusion of a concentrated glucose solution (600 ml 50% glucose = 300 g glucose per day), while the third patient needed treatment with hematin (1 mg/kg body weight, 6 infusions at intervals of 12 hours) because of deterioration of psychic state in spite of glucose infusion. Whenever an attack of AIP occurs, concentrated glucose solution should be administrated as a first measure accompanied by an analgesic and possibly a neuroleptic agent after elimination of precipitating factors. However, if symptoms persist for 48-96 hours or the psychic and/or neurological state of the patient further deteriorates, administration of 1-3 mg hematin per kg body weight can be recommended.

Acute Disease↗
PubMed1991

[Acute sedative effect of a herbal relaxation tablet as compared to that of bromazepam].

The relaxing effect and the systemic tolerance of a single oral dose of Valverde relaxation dragées have been examined double-blinded against 3 mg of bromazepam and placebo in groups of 20 healthy male volunteers each treatment. The systemic tolerance was assessed at the end of the examination, relying on spontaneous remarks or comments made on side effects upon questioning. As the four plants from which Valverde has been extracted (valerian, balm, passion-flower, and pestilence wort) have a reputation of being tranquilizing agents with spasmolytic effect, not only this effect needs to be demonstrated, but also sedative side effects and impairment of vigilance must be assessed to explore the risk for accident proneness. We expected that the relaxing-tranquilizing effect of bromazepam as well as of Valverde relaxation dragées compared with placebo is perceived subjectively. A potentially existing impairment of performance due to Valverde was assumed to be milder than impairment due to bromazepam. The study, however, inspite of a sophisticated test battery with extended testing, could not detect any effect for either of the two drugs; nor could it detect a side effect. The sedation and reduction of vigilance observed in a pre-study without placebo controls (Gerhard and Hobi, unpublished) was explained by natural fatigue which appeared in the course of the morning also under placebo. Therefore, sedative side effects, leading to an impairment in performance, can be excluded for both drugs at the studied dose level.

Adult↗
PubMed1991

[Pregnancy and labor in advanced renal failure due to chronic pyelonephritis].

The rare completion of a pregnancy in the presence of severe chronic renal failure is discussed in 6 cases. In all those cases the renal failure became worse, even though the pregnancy and delivery were satisfactory. Shortly after delivery, the 6 women underwent hemodialysis or peritoneal-dialysis. One patient died several weeks after delivery because of uremia. Our results suggest that for their own safety, women with severe renal failure should not become pregnant.

Adult↗
PubMed1990

[Discrepancy in histopathological findings of curettage material and hysterectomy specimens in malignant tumors of the uterine body].

The clinical staging of the malignoma of the uterine corpus according to the FIGO classification corresponds in only 85.7% in stage I and 35.7% in stage II to the histopathologic staging after operation. Tumor grading and histology from D and C differ in 31.8% and 9.4% respectively from the hysterectomy specimen. We propose therefore to prefer surgical and histopathological staging to the pure clinical FIGO-staging in order to plan adjuvant therapy and for comparing therapeutic results of different patient groups as well.

Adenocarcinoma↗
PubMed1990

[Prenatal care in at-risk pregnancies].

Systematic development of prenatal care is a significant factor in the reduction of maternal and perinatal morbidity and mortality. Despite impressive advances in prenatal and perinatal care, attempts at prevention for most serious pregnancy complications are limited by the lack of sensitive and specific indicators allowing prediction with any degree of probability. In view of the widening spectrum of methods for the diagnosis of pregnancy complications, the dangers of broad application without a critical benefit/risk analysis must be stressed. Apart from rising costs, the effect on pregnant women in terms of increased anxiety must be borne in mind. For the majority of women the core or prenatal care must remain conventional clinical examination combined with extensive consultation and information. Repeated use of technology such as ultrasound, Doppler, cardiotocography etc. should be limited to pregnancies with high risk of serious complications. Invasive preventive measures such as hospitalization, cerclage or administration of tocolytic drugs also need critical use and should be confined to a limited number of genuine high risk cases.

Anxiety↗
PubMed1979

[The effects of a gigant-pulse-laser upon the iris of the pigmented rabbit eye (author's transl)].

The eyes of 10 pigmented rabbits were irradiated by a Q-switched Nd:YAG laser. The pulse energy delivered to the right eye was 187 mJ while the left eye was irradiated with 58 mJ. The pulse duration in both cases was 25 ns. The destructive effects were analysed for two different positions of the focus. In the upper half of the eye the focus was positioned at the anterior iris surface. In the lower half it was adjusted near the pigment epithelium. The eyes were analysed by electron microscopy at intervals of 15 minutes to 128 days after irradiation. The immediate effects were found to depend from the position of the focus but less from pulse energy. At later phases, tissue reaction depends from pulse energy. -- Scarification, at the lower energy level, is almost complete after 32 days. At the higher energy level, degenerative processi are setting in; 3 days after irradiation a progressing iris atrophy is observed which has not yet faded at the 128th day.

Animals↗
PubMedDate not supplied

An esophagobronchial fistula caused by an unusual foreign body in the esophagus leading to mediastinitis with fatal outcome.

An 8(10)/(12) year old girl with infantile cerebral paresis (ICP), severe mental retardation and seizure disorder was admitted to the intensive care unit (ICU) with clinical signs of aspiration and died ten days later. Final diagnosis was esophagobronchial fistula caused by a foreign body in the esophagus provoking aspiration pneumonia, mediastinitis and respiratory distress syndrome (ARDS). The foreign body was found to be part of a plastic toy. The clinical relevance of aspiration in mentally retarded children and the peculiar nature of the foreign body impacted in the esophagus in this case are discussed. We conclude that in cases of aspiration pneumonia in mentally retarded children the presence of unusual foreign bodies should be suspected.

Bronchial Fistula↗