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Biomedical subjects

C Kanellitsas

Publications and source records attributed to C Kanellitsas.

4 recordsLinked to original sources

Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and 145Sm as a brachytherapy source.

A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine, 192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting 145Sm for 192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.

Brachytherapy

An after loading colpostat (using standard source tubes).

An afterloading system for the treatment of gynaecological patients is described. It uses a rigid tandem to which afterloading colpostats are attached. The catheters for afterloading the colpostats are flexible thus minimizing patient discomfort. A constant 90 deg. alignment of source tubes between the uterine tandem and colpostats is achieved.

Cesium Radioisotopes

Analytical approach for depth dose calculations (60Co beams with fixed source-target distance).

A method is described to calculate depth dose distribution to a principal plane using analytical formulas for 60Co teletherapy units and constant source-to-target distance. The formulas were derived from experimental measurements taking into consideration the obliquity of the beam. For the purposes of dose calculation the beam was divided into primary and scattered components. A computer program incorporating the formulas was developed for an IBM 360/67 computer. Dose distributions computed and obtained from experimental measurements were in good agreement. The computer program is now in use for treatment planning, including rotational techniques.

Cobalt Radioisotopes