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Biomedical subjects

C Keane

Publications and source records attributed to C Keane.

50 records · Page 3Linked to original sources
PubMed1976

Gentamicin dosage in children.

The results of 49 serum gentamicin assays from children of 2 weeks to 11 years of age are presented. The dose of gentamicin given 8-hourly intramuscularly ranged from 0-7 mg/kg-4-9 mg/kg. Doses of 1-7 mg/kg or less did not give adequate serum concentrations. As a result of these observations it is suggested that an intramuscular dose of 2-5 mg/kg given 8-hourly is suitable for most children in the absence of renal failure, but that adjustment of the dose according to serum gentamicin concentration is necessary.

Bacterial Infections↗
PubMed1976

The prevalence of ampicillin, cephalosporin and sulphonamide resistance amongst urinary tract pathogens.

A total of 2,031 clinical isolates of Gram negative bacilli was obtained from hospitals in 4 centres and these cultures were tested for resistance to ampicillin, cephazolin and sulphonamide. Ampicillin and sulphonamide resistance in outpatients ranged from 15 to 28 per cent of E. coli strains and 4 to 11 per cent of Proteus mirabilis strains. Resistance to cephazolin in outpatients ranged from 0 to 3 per cent of E. coli and 0 to 6 per cent of Proteus mirabilis. Resistance patterns for E. coli, Proteus mirabilis and Klebsiella strains isolated from inpatients were much higher and varied widely. These patterns are presented and the reasons for these variations discussed.

Ampicillin↗
PubMedDate not supplied

Escherichia coli O157:H7--two case reports.

Since the early 1980s the reports of infection and illness associated with Escherichia coli O157:H7 have increased dramatically worldwide, and particularly in the USA, Canada and UK. The spectrum of disease varies from asymptomatic carriage to haemorrhagic colitis and haemolytic uraemic syndrome (HUS). This infection is new to Ireland, and we report on 2 cases of isolation which outline the presentation of this organism with haemorrhagic colitis and HUS.

Adult↗
PubMedDate not supplied

Sexually transmitted diseases as seen by general practitioners in Ireland: use of a telephone survey.

A telephone survey of one of every five general practitioners in the Republic of Ireland was carried out in July 1978 for the purpose of establishing the frequency of diagnosis of venereal diseases during the preceding year. In addition, information was obtained on the subsequent management of the diseases. This type of survey was found to be economical and quick, and the response rate (98.6%) was excellent. The national frequency of diagnosis (per 100,000 population) was estimated from the sample to be 7.7 for syphilis, 97 for gonorrhea, and 2,000 for nonspecific venereal diseases. The rates of reporting of these diseases were less than or equal to 24.3%, 9.8%, and 3.1%, respectively, of the estimated frequencies. Sixty-nine percent of the general practitioners treated the patients themselves; 51% treated on the basis of clinical diagnosis alone.

Family Practice↗
PubMedDate not supplied

Guidelines for the management of Helicobacter pylori-related upper gastrointestinal diseases. Irish Helicobacter Pylori Study Group.

The discovery of H. pylori is the most important development in gastroduodenal disease this century. It has completely changed our understanding of conditions that occur in the upper gastrointestinal tract. Eradication of the bacterium will cure peptic ulcer disease, decrease the symptoms of non-ulcer dyspepsia and may prevent gastric cancer. There has been an exponential increase in the amount of research in this area in recent years and, consequently, there is considerable confusion as to how H. pylori-related conditions should be managed. It is hoped that these guidelines will clarify some of these issues.

Adult↗