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Biomedical subjects

C Kechrid

Publications and source records attributed to C Kechrid.

16 recordsLinked to original sources
PubMed1990

[Continuous ambulatory peritoneal dialysis in Tunisia].

CAPD covers about 4% of renal replacement therapy patients in Tunisia. From February 1983 to 1988, 47 patients, 21 males and 26 females whose mean age was 36, 14 +/- 15 were treated. Their socio-cultural level was variable. The mean duration of therapy was 14.5 months/patient/year. The five years patient survival rate was 46% and the technique survival rate 21%. Most patients had a good general condition and were professionally rehabilitated. Peritonitis was the main complication: its incidence was 1.8 episodes/patient/year. Yeasts peritonitis were relatively frequent, specially in patients who had previously been treated with antibiotics. Peritonitis was often cured with a local and general treatment. Yearly CAPD cost was 1/3 lower than center hemodialysis and a better management allowed to decrease the expenses due to laboratory and X ray investigations and to hospitalization. On the basis of this clinical experience, we believe that CAPD is an efficient and valid therapeutic modality, less expensive than hemodialysis. It is probably a suitable renal replacement therapy in other centers in Tunisia and in other developing countries.

Humans↗
PubMed1990

[The first thirty months of kidney transplantation in Tunisia].

Kidney transplantation is actually the best replacement therapy for the end stage renal failure. It sets free the hemodialysed patient from the hemodialysis restraint and contributes to solve the socio-economic problems risen by chronic hemodialysis. The authors report the results of this technic during the first 30 months of kidney transplantation in the "Hôpital Charles Nicolle" of Tunis. They describe the first steps which led to kidney transplantation, the therapeutic regimens, the medico-legal problems and the specific complications observed during this start period.

Costs and Cost Analysis↗
PubMed1986

[Treatment of chronic renal failure in Tunisia].

Treatment of end-stage renal disease started in Tunisia in 1968 and has been used for 543 patients; 364 of them are still living. There are now 10 centers, 4 in public hospitals and 6 in private centers. Transplantation is still performed abroad. Among living patients, 312 (86%) are on hemodialysis, 11 (3%) are on CAPD and 41 (11.2%) are living with a transplanted kidney. The mean survival rate of patients is similar to the European mean and professional rehabilitation is good in most cases. New dialysis centers are planned to open and renal transplantation with related living donors will probably be performed soon.

Adult↗
PubMed1985

[Prospective study of a triple immunosuppressive combination in renal transplantation: cyclosporin A-corticoids-azathioprine].

Cyclosporin A significantly improves patient and graft survival as compared with the conventional corticosteroid-azathioprine treatment. However, the results are the same, or even worse, when the cyclosporin A-corticosteroid regimen is compared with the corticosteroid-azathioprine-antilymphocyte globulin regimen. The authors have investigated a prednisone-azathioprine-low dose cyclosporin A combination in 46 high risk patients from a series of 117 renal transplantations performed in 1983. The actuarial patient and graft survival rates were as good as, but not better than, those obtained in 1982 in 106 patients treated with the conventional regimen which includes antilymphocyte globulin; they were 96.5% vs 98% and 85.5% vs 84% respectively at 6 months; 96.5% vs 98% and 83.5% vs 84% respectively at 12 months. The low dosage utilized (8 mg/kg instead of the usual 14-17 mg/kg) avoided virtually all the extrarenal side-effects of cyclosporin A, but not its nephrotoxicity. The theoretical risk of excessive immunosuppression was not confirmed by our study. Since cyclosporin A is very expensive, other therapeutic methods for optimal usage of that drug should be investigated.

Azathioprine↗
PubMed1985

[Role of serum and urinary Tamm-Horsfall protein in the surveillance of kidney transplants].

The study of 24-h urinary excretion proves to be quite interesting from a theoretical point of view on account of its topographic origin in the nephron and from a practical point of view to control renal transplant patients with favourable or unfavourable course. In both cases, the results we obtain are in accordance with that of blood creatinine assay and ratio N-acetyl-beta-D-glucosaminidase (NAG)/creatinine in urine. The prolonged study of serum THG concentration confirms the previous data regarding the outcome of renal grafts. Moreover, particularly low concentration rates probably imply the interference of factors such as: renal toxins or anti-THG autoantibodies.

Acetylglucosaminidase↗
PubMed1982

[Usefulness of combined captopril-labetalol treatment in resistant hypertension (author's transl)].

Fifteen patients with severe or malignant resistant arterial hypertension were treated by simultaneous administration of captopril and labetalol. Seven patients (group A) were given captopril alone and 8 patients (group B) labetalol alone without noticeable results. However, when the two drugs were given jointly a significant fall in mean arterial pressure from 165 +/- 19.8 (+/- 1 S.D.) to 102.4 +/- 15.1 mmHg (p less than 0.001) in group A patients and from 162.7 +/- 20 to 117 +/- 21.4 mmHg (p less than 0.05) in group B patients was observed. There were no significant changes in heart rate, a few side-effects were recorded. The captopril-labetalol combination may be considered as a useful alternative treatment of resistant arterial hypertension.

Adolescent↗
PubMed1981

[Combined captopril and labetalol treatment of malignant arterial hypertension (author's transl)].

Five patients with malignant arterial hypertension and terminal (3) or advanced (2) renal failure were treated with the alpha-beta blocker labetalol and the angiotensin-converting enzyme inhibitor captopril. Labetalol alone or in combination with other antihypertensive agents had been ineffective in two cases and captopril alone in one; yet hypertension was rapidly controlled when the two drugs were given together. The return of blood pressure to normal levels brought about regression of digitalis-resistant cardiac failure in 2 patients and slight improvement of renal function in 2 other patients. The captopril-labetalol combination probably has a synergistic effect, and although its mechanism remains obscure this effect may be used to treat patients with severe or malignant arterial hypertension.

Adult↗
PubMedDate not supplied

[Osteoarticular amyloidosis in hemodialyzed patients. Report of 4 cases].

Chronic hemodialysis is sometimes complicated by an osteoarticular amyloidosis, which happens after a middle delay of ten years, it can be expressed by a tunnel carpal syndrome, a shoulder pariarthritis, bony cysts, and erosive spondylarthropathy. The authors reported their experience about four cases, and insisted on some évocatoring radiologic aspects.

Adult↗