PubMed Health⌕ Search

Biomedical subjects

C Kellner

Publications and source records attributed to C Kellner.

At least 19 recordsLinked to original sources
PubMed2001

[Effect of duration of phacoemulsification on postoperative inflammation--a retrospective study].

BACKGROUND: The early postoperative inflammation after cataract surgery is mainly caused by surgical trauma. PATIENTS AND METHODS: 450 data-sheets of patients, who were operated for senile cataract with small-incision phacoemulsification and in-the-bag implantation of a foldable intraocular lens were retrospectively analysed. Postoperative inflammation was evaluated with the Laser Flare-Cell Meter Kowa FC-1000 on day 1, 3, 7 and 28. All the operations were done with the same phacomachine model Orbit Oertli. The absolute phacotime was measured, the data classified in steps of 20 seconds. Statistical analysis was made with the student's t-test. RESULTS: In the first postoperative week there is a statistical significant difference in the flare-values between the groups with short phacotime (up to 39 seconds) and the group with long phacotimes (over 80 seconds). One month after operation this significance was absent. CONCLUSIONS: The early postoperative inflammation is influenced by the duration of phacoemulsification. Surgical techniques and phacomachines that may reduce phacotime are helpful with respect to early postoperative inflammation.

Aged↗
PubMed2001

The influence of age on the response of major depression to electroconvulsive therapy: a C.O.R.E. Report.

As part of a C.O.R.E., multi-site longitudinal study comparing continuation electroconvulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, > or =65 years; 46-64 years; and < or =45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

Age Factors↗
PubMed1997

Multiple ECT late in the course of neuroleptic malignant syndrome.

We report a 19-year-old woman who received electroconvulsive therapy (ECT) late in the course of neuroleptic malignant syndrome (NMS). She received at least two sessions with multiple ECT and had a full recovery. We suggest that multiple seizures may optimize ECT treatment in NMS.

Adult↗
PubMed1995

[Effect of CPAP and BIPAP on stroke volume in patients with obstructive sleep apnea syndrome].

We studied the effect of CPAP and BIPAP on cardiac output (CO) in 23 male obstructive sleep apnea (OSAS) patients with cardiac history but without congestive heart failure (CHF) during wakefulness using the thermodilution method. CPAP was applied at 10 cm H2O and 15 cm H2O, BIPAP at 10/0 cm H2O and 15/10 cm H2O. CO only decreased significantly by 14.6 +/- 11.8% at 15 cm H2O CPAP and by 13.4 +/- 10.0% at 15/10 cm H2O BIPAP. CPAP and BIPAP did not differ in altering hemodynamics. So sleep apnea patients without CHF develop no severe decrease of CO during nasal positive pressure ventilation up to 15 cm 2O.

Adult↗
PubMed1994

Percutaneous burrhole trephination of the skull: a study of 519 cases.

We want to report on our experiences with the percutaneous trephination using a 2.35 mm round dental drill with serrated saws around it, a "Rosenbohrer". It is a methodically similar activity as described by J. Zentner [11]. From 1981 to 1992 519 patients were treated and 546 trephinations were performed. At the beginning this treatment was only used in connection with intracerebral bleedings and biopsies. In a considerable short time the indication could be extended to the subdural hematoma, tumor cyst, obstructive hydrocephalus as well as to the abscess and the subdural epyema. The rate of infection was 1.28% and the risk of bleeding 0.36%. In our opinion the advantages of this small electrical trephination are the easy handling, the universal use and mobility and the avoidable risk of anesthesia as well as the sterilisation at the same time and the stopping of blood, caused by the contact surface friction.

Adolescent↗
PubMed1993

Cardiovascular effects of imipramine, fluvoxamine, and placebo in depressed outpatients.

BACKGROUND: The data presented represent cardiovascular parameters collected from one site of a larger, multicenter, double-blind, placebo-controlled, 6-week outpatient efficacy study of the serotonin uptake inhibitor fluvoxamine in depressed outpatients. METHOD: In this smaller study, we compared fluvoxamine (N = 17) to the prototypic antidepressant, imipramine (N = 14), and to placebo (N = 15). Specific parameters investigated were drug effects on postural pulse and blood pressure changes and ECG parameters including PR, QRS, and QTc intervals and ventricular heart rate. RESULTS: Fluvoxamine had few effects on measured parameters. Imipramine produced statistically significant changes on all measures; placebo had no effects on cardiac measures. CONCLUSION: Our data support that fluvoxamine, in a sample of healthy depressed outpatients, has little effect on cardiovascular function. Further study and clinical experience with this drug will be necessary before the full extent of its cardiac profile is known.

Adult↗
PubMed1993

[Ambulatory monitoring of patients with suspected sleep apnea syndrome using a thermistor sensor in comparison with nocturnal polysomnography].

Simple ambulatory monitoring methods can be used in step-by-step diagnosis of sleep apnoea syndrome to differentiate between high-risk and low-risk patients, or to exclude the syndrome for achieving more efficient utilisation of sleep laboratory facilities. The question was whether a new method using a thermistor sensor measuring respiration-conditioned thermal convection at the mouth and nose can reliably record the frequency of apnoea (ambulatory thermistor method = ATM). The study was subdivided into two sections. In phase I the respiratory impulses measured via ATM were polygraphically recorded in 20 patients simultaneously with conventional cardiopulmonary data of nocturnal polygraphy (heart rate, oxygen saturation, thorax and abdominal excursions and oronasal respiratory flow). 40 patients participated in phase II. During a first night the patients slept under ATM in their patient rooms. In the 2nd night nocturnal polygraphy was conducted with the parameters mentioned above; the results of both nights were then compared. Taking 35 phases of apnoea in one night as threshold or baseline value, a sensitivity of 100% and a specificity of 84.6% were attained in phase I, the simultaneous comparison of ATM and nocturnal polygraphy, in the recording of an enhanced nocturnal apnoea frequency by ATM. In phase 2 (1st night ATM, 2nd night polygraphy) ATM also yielded a sensitivity of 100% and a specificity of 76%. When measuring with a borderline value of 70 nocturnal phases of apnoea, ATM yielded a specificity and sensitivity of 100%, in phase 2 a sensitivity of 80.7% and a specificity of 88.5%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

[Continuous noninvasive blood pressure measurement in obstructive sleep apnea syndrome without and with CPAP therapy].

The obstructive sleep apnea syndrome is accompanied with episodic increases of systemic blood pressure (B.P.) and possibly with persistent hypertension. to find out the influence of nCPAP therapy on systemic blood pressure in sleep apnea patients, 10 patients (apnea index 9-51/h) were monitored by means of continuous noninvasive blood pressure measurement during polygraphy, circulation was examined before and 2-7 days after CPAP therapy. Every 30 minutes a 2-minute period of the systolic and diastolic B.P. was visually averaged and from these data the mean pressure of 7 hours nocturnal sleep was calculated. The mean systolic pressure before therapy was 139 +/- 32 mmHg and decreased to 122 +/- 14 mmHg under nCPAP (significant), the mean diastolic pressure before therapy was 74 +/- 17 mmHg and decreased to 64 +/- 8 mmHg under nCPAP. The maximal B.P. during the 7-hour measurement decreased from 155 +/- 27 mmHg to 137 +/- 20 mmHg under nCPAP.

Adult↗
PubMed1992

Vasopressin regulates human sleep by reducing rapid-eye-movement sleep.

In two double-blind experiments, effects of intravenous infusion of arginine vasopressin (AVP) on sleep were evaluated in 2 groups of 10 men (20-35 yr). In experiment I, subjects were tested on two occasions, during which they received either placebo or 0.33 IU/h AVP. In experiment II, on three different occasions, subjects received either placebo or 0.66 or 0.99 IU/h AVP. Infusions were administered between 2200 and 0700 h. Nocturnal plasma AVP concentrations were close to the upper limit of the normal physiological range during 0.66 IU/h AVP (16.6 +/- 2.2 pg/ml) but markedly exceeded this range during 0.99 IU/h AVP (25.0 +/- 1.6 pg/ml). Results indicate primary effects of AVP on rapid-eye-movement (REM) sleep, with moderate reductions in REM sleep during 0.33 IU/h AVP (averaging -10.5%) and with substantial reductions in REM sleep (-24.0%) during 0.66 IU/h AVP. During 0.99 IU/h AVP the effect did not further increase (-24.4%). Less consistent effects of AVP were an increase in stage 2 sleep and in time awake. Effects of AVP were not mediated by changes in cortisol or blood pressure. Results suggest AVP to participate in REM sleep regulation under normal physiological conditions.

Adult↗
PubMed1989

[Boerhaave syndrome. The differential diagnosis of acute retrosternal pain].

A 10-cm-long longitudinal tear in the middle third of the oesophagus--with intact deeper muscle layers--was found endoscopically in a 52-year-old alcoholic man who had developed acute retrosternal pain after severe vomiting. There was a leukocytosis of 16,700/microliters and fever of 38.8 degrees C. Because of the diagnosis of incomplete spontaneous oesophageal rupture (Boerhaave syndrome) he was fed parenterally, a gastric tube was placed, and he received three times daily 2 g ampicillin, twice daily 80 mg gentamicin and 1.2 g cimetidine. The fever disappeared after 24 hours and the leukocytosis regressed after four days. At repeat endoscopy after 16 days the tear had healed completely.

Acute Disease↗
PubMed1987

Corneal endothelial cell damage associated with contact to gas bubbles during YAG laser application.

Corneal endothelial cell damage was generated in freshly enucleated pig's eyes by multiple applications of YAG laser bursts in the anterior chamber focussed 2 mm behind the corneal endothelium. With 100 X 5 bursts at an energy of 5 mJ focussed 2 mm behind the endothelium, a considerable number of gas bubbles were generated at the site of optical breakdown in the aqueous humor. Variable areas of scattered endothelial cell damage or necrosis were observed. By selecting two different experimental settings, a possible harmful effect of the gas bubbles on the corneal endothelium could be demonstrated.

Animals↗
PubMed1986

[Side effects of YAG laser treatment].

In enucleated pig eyes endothelial cell damage was demonstrated after YAG laser coagulation. The extent of the damage can be correlated to the distance between the laser focus and the endothelium, and to the energy. Similar effects and correlations can be demonstrated on intraocular implant lenses in an experimental model.

Animals↗