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Biomedical subjects

C Kessler

Publications and source records attributed to C Kessler.

At least 199 records · Page 11Linked to original sources
PubMed1982

Competition of rifampicin with binding of substrate and RNA to RNA polymerase.

The rate of formation of dinucleoside tetraphosphate, pppApU, from ATP and UTP by RNA polymerase on the A1 promoter of the mutant D111 of bacteriophage T7 is distinctly and specifically reduced not only by the third template-directed nucleotide, CTP, but also by CMP. The inhibitory effect of CMP is not changed when the enzyme contains prebound rifampicin. The synthesis of pppApU is also strongly reduced after preincubation of the enzyme with RNA. This inhibitory effect of RNA is, however, distinctly diminished by rifampicin bound to the enzyme prior to the addition of RNA. On the other hand RNA can suppress the specific binding of the antibiotic to the RNA polymerase subassembly alpha 2 beta.

Bacterial Proteins↗
PubMed1982

[Platelet scintigraphy using indium-111].

Platelet scintigraphic examination using indium-111 was performed on 12 patients with cerebral ischemia. Of these patients 5 had a history of TIA, 3 had a prolonged reversible neurologic deficit (PRIND), 3 cases were presented with a completed stroke and 1 patient suffered from a suspected venous thrombosis of the sinus sagittalis superior. In total 8 cases showed pathological platelet accumulations in the vessel clinically affected, 5 extracranially and 3 intracranially. In the other 4 cases the platelet scintigraphy was normal. The cases with TIA showed pathological platelet accumulations in the appropriate vessel, even if the angiogram was normal. On the other hand platelet scintigraphy did not show any abnormality in 2 patients with an occlusion of the carotid artery. So platelet scintigraphy might be useful in the detection of small arterial lesions producing small strokes, and which remain undetected by other diagnostic methods.

Adult↗
PubMed1977

A comparative analysis of methods suitable for detection of platelet alloantibodies: inhibition of 14C-serotonin uptake, 14C-serotonin release and microcomplement fixation.

Three HLA-specific antisera were comparatively analyzed by platelet microcomplement fixation and 14C-serotonin uptake and/or 14C-serotonin release studies with platelets. In general, there was a good correlation of HLA antibody specificity exhibited in all 3 test systems. Quantitative differences in the response of platelets to HLA antisera were observed and accounted for by differences in antigen density and different types of antibodies involved. Platelet autoantibodies could not be detected by means of 14C-serotonin release from platelets in plasma.

Antibody Specificity↗
PubMed1977

An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels.

Sulpiride is a new and chemically different neuroleptic. In a study of 16 severely ill schizophrenic patients, this compound displayed definite evidence of antipsychotic activity while producing few adverse reactions. The relative absence of extrapyramidal side effects may indicate that sulpride has a low potential for producing tardive dyskinesia. Two patients who did not develop significant increases in prolactin levels did show a definite therapeutic response to sulpiride. Thus it appears that central dopaminergic blockade in the hypothalamic area is not a prerequisite for antipsychotic activity.

Adult↗
PubMed1977

Sulpiride: evaluation of antipsychotic activity in schizophrenic patients.

Sulpiride is a new antipsychotic agent chemically different from recognized psychotropic compounds. The animal profile and the rapid urinary excretion without metabolism also distinguishes this drug from other neuroleptics. Previous studies have indicated therapeutic efficacy and few side effects. Sulpiride was evaluated in 10 hospitalized, chronic schizophrenic patients over a 10 week period. The overall findings support those studies reporting neuroleptic activity. Although no side effects were encountered, a mild leukocytosis was observed in one patient and broadening and flattening of T-waves was observed in another when each received high doses. Toxic levels appear to be well beyond the therapeutic range.

Adult↗