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Biomedical subjects

C Koutsandrea

Publications and source records attributed to C Koutsandrea.

13 recordsLinked to original sources

Optical coherence tomography in the study of the Goldmann-Favre syndrome.

PURPOSE: To report a case of Goldmann-Favre syndrome with special emphasis on the optical coherence tomography findings. METHODS: In a 23-year-old white man with an 8-year history of visual impairment in both eyes and night blindness, vertical and horizontal optical coherence tomography images were obtained through the macula and through the retinoschisis located at the temporal side of the macula. RESULTS: Optical coherence tomography showed in the left eye a clear loss of the inner retinal layer at the fovea and the formation of inner and outer retinal layer holes in the temporally located retinoschisis. The outer retinal layer hole had rolled edges. CONCLUSION: In Goldmann-Favre syndrome, optical coherence tomography demonstrated confluent macular cystoid changes and retinoschisis in both eyes. In the left eye, a lamellar macular hole and retinoschisis with inner retinal layer and outer retinal layer holes were observed. The outer retinal layer hole had rolled edges.

Adult↗

Cyst formation in optic disc pit maculopathy.

PURPOSE: To evaluate the presence and the evolution of cyst formation in optic disc pit maculopathy. METHODS: In this prospective study, 18 cases with optic disc pit maculopathy were studied. Five of them showed cyst formation in the fovea at the initial examination. The fundus findings were documented with slit-lamp biomicroscopy, indirect ophthalmoscopy, and stereoscopic photography of the posterior pole. All 5 patients were treated with a macular scleral buckle procedure. RESULTS: The presence of cysts in the elevated macula depends on the grade of the disease. Cyst formation can develop not only in the later stage of the disease but also quite early. In all 5 patients cyst formation gradually decreased and finally disappeared after the surgical procedure. CONCLUSIONS: Cyst formation is an entity which accompanies the macular detachment associated with optic disc pit. The development of the cysts has been noticed after the establishment of the schisis-like separation and before or in conjunction with the formation of a lamellar macular hole which usually accompanies the optic disc pit maculopathy.

Adolescent↗

The use of tissue plasminogen activator in postvitrectomy cases.

The study concerns 17 eyes which, following vitrectomy, were given an injection of 25 micrograms of tissue plasminogen activator (tPA). Of these 17 cases, ten showed a severe fibrin formation in the anterior chamber, 3 cases showed vitreous hemorrhage (one of them with hyphema), 2 had fibrin formation and cellular proliferation, while in one case tPA was injected at the end of the vitrectomy because of perisilicone proliferation and in one case because of fibrin depositions on the intraocular lens. The tPA was injected into the anterior chamber (10 eyes) or into the vitreous cavity (7 eyes). The follow-up period ranged from 4 to 15 months (mean period 9 1/2 months). Fibrinolysis was noted in the 10 cases with fibrin formation in the anterior chamber. Fibrin dissolution was achieved within 3-4 hours. None of these cases presented a recurrence throughout the follow-up period. Positive results were observed also in the case with perisilicone proliferation. On the contrary in 3 cases with postvitrectomy hemorrhage the hemorrhage persisted unchanged. Also in 2 cases with fibrin formation and cellular proliferation on the anterior and posterior surface of the iris the tPA injection proved ineffective. Both cases developed traction retinal detachment (TRD) due to anterior proliferative vitreoretinopathy (PVR). In the case with fibrin depositions on the intraocular lens the situation remained unchanged. Any complications observed in our case proved to be mild and transitory.

Adolescent↗

Central visual field changes after panretinal photocoagulation in proliferative diabetic retinopathy.

This study comprises 53 eyes, divided into two groups A and B, with proliferative diabetic retinopathy which were treated with panretinal photocoagulation (PRP). Its purpose is to investigate the alterations in the central 15 degrees and 30 degrees of the visual field and in each quadrant separately. In both groups A and B, PRP covered the periphery and mid-periphery. In group A, it stopped 2 disc diameters (DD) from the upper temporal and lower margin of the fovea including the papillomacular bundle, while in group B, PRP stopped 3 DD from the upper temporal and lower margin of the fovea and 1 DD of the nasal margin of the optic disc. The investigation revealed, in group B after PRP, an improvement of the retinal sensitivity in the central 15 degrees of the visual field (p less than 0.01). In the 30 degrees of the visual field a deterioration after PRP was noted in both groups A and B, the deterioration being however much more prominent in group A. Comparing the results between groups B and A after PRP, a difference in the retinal sensitivity in favour of group B at 15 degrees and 30 degrees of the visual field was found. As regards regression of neovascularization and visual acuity, no statistically significant difference has been observed between the two groups.

Adult↗

A comparative study concerning the treatment of active toxoplasmic retinochoroiditis with argon laser and medication (follow-up 2-9 years).

Thirty-three eyes (i.e. 33 patients) with active toxoplasmic retinochoroiditis were treated and followed up for a 2 to 9 year period. The patients were divided into two groups. The first was treated with laser, while the second received medication. The division into two groups was made in order to discover possible differences between the two groups concerning success rate, time of regression of the lesion recurrences and complications. The study showed the following results: there was no difference as to the rate of overall success between the two groups. The laser produced no result in the cases where the active retinochoroidal lesion was larger than 2 disc diameters. The regression of the active lesion in the laser group was accomplished in 25-50 days, while in the medication group took 50-150 days. Recurrences after treatment were found in both groups. However, the starting point of recurrences differed in each group.

Adolescent↗

[Pulsatile arterial macroaneurysm: management with argon laser photocoagulation].

Retinal arterial macroaneurysms (RAMs) represent wall dilatations of the retinal arteries most commonly found in elderly, hypertensive women. They are usually asymptomatic, non pulsatile, spontaneously resolving entities. However visual loss may occur secondary to macular edema, exudate and hemorrhage. We present a case of a pulsatile RAM of a 58 year old, hypertensive, one eye woman suffering progressive visual loss. She was immediately treated with indirect laser photocoagulation. Eight weeks later there was a prominent resolution of both edema and hard exudates with an impressive increase of the visual acuity. Since indications for photocoagulation and treatment modalities remain uncertain we present the case to emphasize the necessity of immediate treatment of special cases.

Aneurysm↗

[Optic disk and choroidal coloboma].

Most of the optic nerve head abnormalities are clinically innocuous, but sometimes they can cause significant symptoms and lead to visual disturbance, or even to visual loss; optic pists can cause defects in the visual fields, not necessarily explicable by the serous maculopathy, that is the most important complication associated with optic pits. Our purpose is to present a case of an optic pit with sensory macular detachment associated with a choroidal coloboma located at a distance of two optic disc diameters from the optic nervehead. This finding to our knowledge has not been previously reported.

Adolescent↗

[Choroid effusion in an antiglaucoma operation in a child with Sturge-Weber syndrome].

The authors describe a case of expulsive choroidal effusion which occurred in the course of a fistulating operation in a child with Sturge-Weber syndrome. This is the youngest patient with this complication so far reported in the literature. The persistent postoperative choroidal and retinal detachments in this case led to a considerable diminution of visual acuity.

Angiomatosis↗

[Thalassemia and macular subretinal neovascularization].

A 12 year old boy who suffered from homozygous beta-thalassemia came to our clinic complaining of progressive deterioration of the visual acuity of the left eye. His visual acuity at this eye was finger counting at a distance of 50 cm. Fundus examination revealed a tortuous course of the fundus vessels, angioid streaks radiating from the region of the disk and a greyish elevated circular lesion measuring about half a disk diameter in the macular area. Fluorescein angiography showed the existence of a subretinal new vascular membrane. The possibility of the development of severe fundus complications in patients with thalassemia syndromes is discussed.

Angioid Streaks↗

[Recurring vitreous body hemorrhages due to a retinal vessel drawn into the vitreous body cavity].

Six cases of recurrent vitreous hemorrhage are described. The hemorrhage was due to a retinal vessel rupture or injury caused by vitreous traction. The traction was exerted by the detached vitreous and the vessel drawn into its cavity without the simultaneous occurrence of a tear in the retinal area corresponding to the point of traction. The avulsed vessel was usually a small vein in the upper temporal fundus quadrant. The vessel either projected as a hooklet into the vitreous cavity or its peripheral end was found to be floating freely within the cavity after having moved away from the retina. Treatment consisted in laser coagulation alone or in conjunction with an indentation created by fixing a silicon episcleral explant. Recurrent vitreous hemorrhages caused by a retinal vessel drawn into the vitreous cavity after posterior vitreous detachment without a retinal tear have hitherto not been accorded the attention they deserve.

Adult↗

Late complications in branch retinal vein occlusion.

Neovascularization in branch retinal vein occlusion usually develops 6-12 months after the onset of the disease, although some cases have been reported in which neovascularization and subsequent vitreous haemorrhage developed 2-3 years later. This is a report of nine cases of late appearance of vitreous haemorrhage due to branch retinal vein occlusion, which occurred 3-6 years after the initial onset of the disease. In two of these nine cases the vitreous haemorrhage was very profound and had to be managed by vitrectomy. We have studied the remaining seven cases, which had retinal ischaemia and optic disc or retinal neovascularization documented by fluorescein angiographic examination. Laser coagulation was applied in these seven cases, which resulted in considerable regression of the neovascularization and absorption of the vitreous haemorrhage. In one out of the seven cases recurrent vitreous haemorrhages appeared and it was finally treated by vitrectomy. Visual acuity improved in six of the seven cases. The follow-up period ranged from 12 to 48 months. The late appearance of the ischaemic type of branch retinal vein occlusion with neovascularization can be attributed to the change in character of the initially mild oedematous form of the disease. Partial posterior vitreous detachment and traction exerted at some later stage upon the neovascularization could be additional factors of the late appearance of vitreous haemorrhage. Patients with branch retinal vein occlusion should be followed up regularly over a long period of time in order to avoid late complications of the disease, such as vitreous haemorrhage following optic disc or retinal neovascularization.

Aged↗