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Biomedical subjects

C Krüger

Publications and source records attributed to C Krüger.

At least 91 records · Page 5Linked to original sources
PubMed1979

Leukocyte alkaline phosphatase in malignancies.

The leukocyte alklaine phosphatase (LAP) levels were determined in 183 patients with malignant diseases and 71 normal controls. The median LAP scores were 64 units (range 0 to 290) for the patients and 55 (range 2 to 158) for the controls, respectively, and no significant difference could be established. When analyzed according to primary malignancy, only in patients with Hodgkin's disease (n = 14) was the median value higher than normal (p less than 0.001). In patients with distant metastases (n = 48), higher LAP levels were demonstrated (M = 76, range 21 to 290) as compared to patients with no evidence of metastases (M = 53, range 0 to 229), (p less than 0.01). Thus, LAP activity has very limited value in the diagnosis of malignancies. Its elevation in the presence of malignant disease might, however, indicate metastases.

Adult↗
PubMed1978

Ribosomal RNA synthesis in rat liver cells.

DNA-dependent RNA polymerase A was analyzed in rat liver cells after partial hepatectomy, which is known to enhance the synthesis of ribosomal RNA. In agreement with previous results, it was found that the extractable enzyme activity increased after partial hepatectomy and could be quenched by the subsequent administration of cycloheximide, which suggests that continuous protein synthesis is required for the maintenance of the observed stimulation. However, administration of alpha-amanitin to hepatectomized rats did not quench the enzyme activity. These results cast doubt on the hypothesis that the increased activity of RNA polymerase A observed after partial hepatectomy is mediated by RNA products synthesized by polymerase B. Moreover, data are reported which indicate that ribosomal RNA may be regulated directly, without the obligatory involvement of HnRNA.

Animals↗
PubMed1977

[Late sequelae of rib fractures].

For an assessment of the late lesions after rib fractures 108 patients having had an accident between 1968 and 1973 were followed up. As to the individual signs observed, the patients were very heterogeneous. Radiodiagnostic, spirometric and scintigraphic data were compiled in order to characterize the late morphologic and functional lesions. By means of correlation and discrimination analyses as well as tests of significance we found that the extension of the late lesions depends either on the age of the patient nor on the number of fractured ribs but, instead, on concomitant intrathoracic lesions. The late morphologic lesions such as deformedly healed rib fractures and pleural thickening were the substrate for the ventilative and circulatory disturbances of the lung.

Adult↗
PubMed1975

The contents of acid glycosaminoglycans in the aortic wall of newborns, small children, and older adults.

The contents of acid glycosaminoglycans (aGAG) was determined in the inner and medial layers of aortae from 13 newborns, 9 small children (1-5 years of age), and 10 older adults (7th decade of life). The total aGAG contents was expressed in mug hexuronic acid/100 mg dry weight. Newborns and older adults showed similiar contents of aGAG in their aortae (275.5 plus or minus 27.9 and 313.4 plus or minus 46.7, respectively). Small children had significantly less aGAG in their aortae (202.1 plus or minus 21.5). The aGAG material from aortae was fractionated by a microcolumn chromatographic procedure on cetylpyridinium chloride cellulose. No significant differences of the aGAG fractions were found in aortae of newborns and children. In both groups of children the percentage of hyaluronic acid was significantly increased and dermatan sulfate was significantly decreased when compared with aortae from older adults. The increased contents of acid glycosaminoglycans (aGAG) in aortae of human newborns is possibly caused by the concentrated hormonal environment (especially estrogens) to which the fetus is exposed in utero.

Age Factors↗