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Biomedical subjects

C Kuday

Publications and source records attributed to C Kuday.

27 records · Page 2Linked to original sources
PubMed1997

Blood degradation products play a role in cerebral ischemia caused by acute subdural hematoma.

The pathogenesis of ischemic brain lesions with traumatic hematoma is multifactorial. It has been suggested that the presence of subdural hematoma in patients with severe head injury is associated with elevated intracranial pressure and higher mortality. In this study we created acute subdural mass in the rats by injecting 250 microliters of autologous blood and silicone oil into the subdural space. The goal of this study was to determine the effect of subdural hematoma versus silicone oil on the adjacent brain parenchyma. Twenty-four hours after the injection, of the hematoma in the subdural space in rats produced an extensive zone of underlying ischemic damage but silicone oil did not. This study has shown that pressure alone caused by silicone oil is insufficient to cause significant neuronal damage or loss.

Animals↗
PubMed1996

A new aneurysm wrapping material: polyglactin 910 + fibrin sealant.

Aneurysms experimentally induced by using the silver nitrate coagulation method in 10 Wistar Albino rats are wrapped with Polyglactin 910 and Fibrin Sealant. 6 weeks later the rats are sacrificed and compared with the control group. In the group in which Polyglactin 910 and Fibrin Sealant were used as the wrapping material, non-specific inflammatory granulation tissue development around the aneurysms is observed. We suggest that a Polyglactin 910 and Fibrin Sealant combination can be used as a wrapping material in the treatment of aneurysms where clipping is not possible.

Animals↗
PubMed1995

The significance of neuron specific enolase levels in cerebrospinal fluid and serum after experimental traumatic brain damage.

In the posttraumatic period, measurement of neural tissue enzymes in serum and cerebrospinal fluid gives quantitative information about the severity of the head injury. In our study, we evaluated the relationship between the serum and cerebrospinal fluid levels of neuron specific enolase and the severity of trauma. Head traumas at different severity were applied experimentally (Mild 0.038 N, Moderate 0.057 N, Severe 0.3 N). Serum and cerebrospinal fluid levels of neuron specific enolase were measured in trauma and control groups of rats. Only in the severe trauma group, the neuron specific enolase levels of cerebrospinal fluid were significantly increased. There was no statistically significant difference between the groups when serum neuron specific enolase levels were evaluated. Our data leads us to conclude that trauma, causing significant neural damage, results in an increase in cerebrospinal fluid neuron specific enolase levels, however the serum neuron specific enolase levels do not seem to run parallel with that increase.

Animals↗
PubMed1994

Statistical analysis of the factors affecting the outcome of extradural haematomas: 115 cases.

115 traumatic extradural haematoma cases who were treated surgically at Cerrahpasa Medical Faculty Neurosurgery Department between 1987 and 1992 are evaluated. When factors affecting the outcome were examined, a strong correlation was found between the result and Glasgow coma scale (GCS) (p < 0.00001). The existence of a fracture, the interval between onset of haematoma symptoms and intervention and the existence of an intracerebral haematoma together with contusion accompanying intradural haematoma, affect the outcome in a negative direction. There was no statistical correlation between the outcome and the age of patient, localization of the haematoma and aetiology.

Adolescent↗
PubMed1994

Warburg syndrome.

The case of a newborn who had ocular, cerebral and cerebellar dysgenesis with hydrocephalus, which represents very rarely occurring Warburg syndrome, is described. Clinical, radiographic, and histopathological features are detailed.

Abnormalities, Multiple↗
PubMed1994

Changes in the activity of antioxidant enzymes (SOD, GPX, CAT) after experimental spinal cord injury.

We determined time dependent changes in the levels of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) at 1, 4 and 24 hours after standardized reversible spinal cord injury in rats. In each segment (rostral, lesion, caudal) enzyme activities at 1, 4 and 24 hours were not significantly different. Without time limitation we have found that SOD and GPx activities were not significantly different (p > 0.05), but CAT activity was significantly high (p = 0.008) in the lesion segment than the rostral and caudal segment. According to our results we suggest that one of the main reason for tissue damage during such a spinal cord trauma model may be neither H2O2 nor H2O2 derived radicals.

Animals↗
PubMed1994

The effects of synthetic growth hormone on spinal cord injury.

The aim of this study was to determine the effect of synthetic growth hormone on healing process of reversible injured spinal cord. The rat was selected for the experiment in preference to larger animals for economy and availability. Under general anesthesia one level laminectomy was carried out at T-1 with the dura mater intact. The injury was created by Rivlin and Tator's clip method. Recovery of motor function was assessed for up to 4 weeks using inclined plane test of hind limb motor function. Although the effect of the drug is evident after 3 weeks, the study must be held for longer periods for a sufficient regeneration time to maintain a significant statistical evaluation.

Animals↗