Modification of a model membrane structure by embedded photochrome.
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Azo Compounds↗
Biomedical subjects
C Kumar
Publications and source records attributed to C Kumar.
Clinical and experimental characteristics of "hypothetically psychosis prone" college students.
The study of individuals at the boundaries of schizophrenia has historically involved genetic relatives of schizophrenia patients or individuals who meet criteria for schizotypal personality disorder (SPD). Recently, many investigators have turned to the use of psychometric scales, developed to measure psychotic traits or vulnerability to developing schizophrenia, to screen large populations of college students in order to identify individuals who are "psychosis prone" or "schizotypal". To help answer the question of whether students identified with psychometric scales are indeed psychosis prone, we screened 1115 college students with the Perceptual Aberration/ Magical Ideation (PerMag) and Physical Anhedonia (PhysAn) Scales. Individuals who scored 2 standard deviations (SD) above the mean on the scales were selected as experimental subjects (N = 13 PerMag, N = 10 PhysAn) and a subpopulation of matched subjects who scored less than 0.5 SD above the mean were selected as control subjects (N = 24). All subjects then received a full battery of tests, including structured clinical interviews, the MMPI, and psychophysiological measures of information processing, including prepulse inhibition and habituation of the human startle response, visual backward masking and reaction time measures. The results suggest that the PerMag scale, but not the PhysAn scale, identifies individuals with some psychotic, affective and anxiety symptoms when compared to the controls. Neither scale predicts a diagnosis of schizotypal personality disorder or deficits on measures of information processing that characterize schizophrenia or schizotypal personality disordered patients.
Female↗
Antisense RNA: effect of ribosome binding sites, target location, size, and concentration on the translation of specific mRNA molecules.
A series of plasmids were constructed to generate RNA complementary to the beta-galactosidase messenger RNA under control of the phage lambda PL promoter. These plasmids generate anti-lacZ mRNA bearing or lacking a synthetic ribosome binding site adjacent to the lambda PL promoter and/or the lacZ ribosome binding site in reverse orientation. Fragments of lacZ DNA from the 5' and/or the 3' region were used in these constructions. When these anti-mRNA molecules were produced in Escherichia coli 294, maximal inhibition of beta-galactosidase synthesis occurred when a functional ribosome binding site was present near the 5' end of the anti-mRNA and the anti-mRNA synthesized was complementary to the 5' region of the mRNA corresponding to the lacZ ribosome binding site and/or the 5'-coding sequence. Anti-mRNAs producing maximal inhibition of beta-galactosidase synthesis exhibited an anti-lacZ mRNA:normal lacZ mRNA ratio of 100:1 or higher. Those showing lower levels of inhibition exhibited much lower anti-lacZ mRNA:normal lacZ mRNA ratios. A functional ribosome binding site at the 5'-end was found to decrease the decay rate of the anti-lacZ mRNAs. In addition, the incorporation of a transcription terminator just downstream of the antisense segment provided for more efficient inhibition of lacZ mRNA translation due to synthesis of smaller and more abundant anti-lacZ mRNAs. The optimal constructions produced undetectable levels of beta-galactosidase synthesis.
Binding Sites↗