PubMed Health⌕ Search

Biomedical subjects

C L Abramson

Publications and source records attributed to C L Abramson.

6 recordsLinked to original sources

Computed tomography and magnetic resonance imaging in children with rare movement disorders.

Both CT and MR can aid in the differentiation between benign and less favorable pediatric movement disorders. However, MR is the more sensitive imaging modality and thus preferable. This was demonstrated in 18 patients with conditions ranging from idiopathic dystonias to aminoacidopathies, Leigh's disease, and Hallervorden-Spatz disease. In the latter three entities characteristic lesions were shown in the basal ganglia, although not consistently. A specific diagnosis seems possible in Leigh's disease, provided the clinical setting is appropriate.

Adult↗

MR imaging of intraspinal extension of neuroblastoma.

The CT and magnetic resonance (MR) findings in two children with intraspinal extension of mediastinal neuroblastoma are described. The potential of MR to obviate the need for myelography is discussed.

Child↗

Leigh disease (subacute necrotizing encephalomyelopathy): CT and MR in five cases.

Magnetic resonance (MR) imaging and CT were used in supporting the diagnosis of Leigh disease (subacute necrotizing encephalomyelopathy) in five patients. Two cases were confirmed at postmortem examination, and three patients have laboratory and/or clinical histories suggestive of Leigh disease. Four cases demonstrated findings in the basal ganglia, especially the putamina, with symmetrical areas of low attenuation on CT. Correspondingly, on proton saturation and T2-weighted pulse sequences, these areas showed high intensity signal characteristics by MR. Similar findings were noted in the caudate nucleus (two cases). Magnetic resonance proved to be superior to CT in establishing other areas of involvement: tectum and tegmentum (one case) and medullary olive (one case). Pathology identified these lesions as representing necrosis. Magnetic resonance may be diagnostic in the appropriate clinical setting.

Brain↗