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Biomedical subjects

C L Cetrulo

Publications and source records attributed to C L Cetrulo.

64 records · Page 4Linked to original sources
PubMed1977

Relation between optical density at 650 nm and L/S ratios.

A simple and rapid test that correlates with L/S ratios has been developed. By centrifuging fresh, unfrozen amniotic fluids at 200g for 10 minutes and measuring the optical density at at 650 nm, correlation with L/S ratios is obtained. Optical density readings of 0.15 or greater correlate 100% with L/S ratios of 2.0 or greater. Optical readings below 0.15 correlate 94% with L/S ratios below 2.0.

Amniotic Fluid↗
PubMed1976

Ritodrine HCL for the prevention of premature labor in twin pregnancies.

The perinatal mortality rate for twin gestation is in the range of 15%, and this is due predominantly to prematurity, although twins may also be born growth retarded. Ritodrine HCl, a beta sympathomimetic drug, has been shown to be effective, both in stopping premature labor and in preventing intrauterine growth retardation. With this in mind, a double-blind study using ritodrine HCl or placebo was begun in order to study its effect on premature labor, intrauterine growth retardation, and the perinatal mortality rate in twins. Thus far, 30 patients have delivered and have been followed to 6 weeks postpartum. Although the results on individual patients have remained blinded to the investigators, an initial evaluation of the ritodrine and placebo groups have revealed no difference with respect to gestational age, birth weight, or perinatal mortality. These preliminary results are not significant. However, it appears that ritodrine HCl is a safe oral agent for the antepartum gravida and her fetus. The study will be continued until approximately 100 patients have been enrolled.

Clinical Trials as Topic↗
PubMed1976

Correlation between amniotic fluid optical density and L/S ratio.

A test that circumvents the complex methodology needed for the determination of L/S ratios has been developed. It has been observed that the optical density, measured at 400 nm, of supernatants collected from fresh amniotic fluids centrifuged at 2000 g for 10 minutes correlates with L/S ratios.

Amniotic Fluid↗
PubMed1976

Fetal heart rate patterns preceding death in utero.

Four cases of intrauterine fetal demise in term infants are presented. From these cases and other published reports, a sequence of fetal heart rate changes preceding intrapartum death is presented. Late or variable decelerations, if unrelieved or uncorrected, lead to baseline heart rate changes of tachycardia and loss of variability reflecting loss of fetal reserve and fetal distress. This is followed by an unstable heart rate, a sinusoidal pattern, or a rapidly changing fetal heart rate. The final event is a profound bradycardia just prior to fetal demise.

Asphyxia Neonatorum↗
PubMedDate not supplied

Fetal lung to liver reflectivity ratio and lung maturity.

A pilot study examined 23 patients who underwent simultaneous ultrasound and amniocentesis to determine whether the ratio of densitometrically determined tissue densities of fetal lung and liver correlate with the L/S, the OD 650, or phosphatidylglycerol levels. The incidence of a lung/liver ratio greater than 1 of 65% was similar to that of maturity levels of the standard tests. However, there was no statistically significant correlation between an L/L greater than 1 and/or any maturity parameter tested, nor was there any correlation with the absence of pulmonary maturity. We conclude that this test cannot be reliably used to predict L/S, OD 650 reading, or PG levels.

Female↗