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Biomedical subjects

C L Chander

Publications and source records attributed to C L Chander.

23 records · Page 2Linked to original sources
PubMed1989

Myofibroblasts in cotton-induced granulation tissue and the bovine adrenal capsule: morphological aspects.

Ultrastructural studies of one week old cotton-induced granulation tissue revealed the presence of polymorphonuclear neutrophils (PMN), macrophages and mast cells, whilst the granulation tissue from two week old cotton implants contained fibroblasts, myofibroblasts and abundant collagen fibres. Similarly, the bovine adrenal capsule contained both fibroblasts and myofibroblasts. It is proposed that the bovine adrenal capsule and two week cotton-induced granulation tissue could be utilized as in-vitro models to study the mechanism(s) involved in myofibroblast contraction.

Adrenal Glands↗
PubMed1989

Cellular interaction in cartilage degradation.

Rat femoral head cartilages (FHCs) in culture for six days retained their glycosaminoglycan (GAG) content and were not affected by recombinant human interleukin-la (IL-1), conditioned media from concanavalin-A stimulation of sensitized lymphocytes (lymphocyte media), or conditioned media from lymphokine-stimulated macrophages (macrophage media). Similarly FHCs cultured with macrophages in the presence of IL-1, lymphocyte medium or macrophage medium did not suffer a loss of GAG. However, FHCs cultured with fibroblasts showed a substantial loss of GAG. This fibroblast-mediated cartilage degradation was significantly increased by IL-1 and macrophage media respectively. Stimulation of fibroblasts by lymphocyte media failed to increase the loss of GAG. It is proposed that cartilage degradation in inflammatory joint disease is brought about by a sequential cell-to-cell interaction via cytokines leading ultimately to stimulation of fibroblast-mediated cartilage degradation.

Animals↗
PubMed1989

A cytochemical study of the adjuvant inflamed air pouch in the rat.

The oxidative biochemistry of the adjuvant-inflamed rat air pouch has been studied using the techniques of quantitative cytochemistry. Highly significant increases in the maximal activities of glucose-6-phosphate dehydrogenase, lactate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase were observed. These changes are similar to those that have been reported by others in both human rheumatoid synovial tissue and the synovial tissue of rabbits with allergic arthritis. It is suggested that modulation of these changes by putative therapeutic agents may form the basis for a readily quantifiable drug screening programme.

Adjuvants, Pharmaceutic↗
PubMed1988

The local modulation of vascular permeability by endothelial cell derived products.

Endothelin has been shown to suppress increased vascular permeability in the rat at doses of 0.01 pmol. The agonists used were nitric oxide and nitroprusside, which have the same activity as endothelial-derived relaxing factor. Histamine, 5-hydroxytryptamine, platelet activating factor and carrageenan were the other agonists used. It is proposed that endothelin and EDRF act as local hormones produced by endothelial cells to control local vascular permeability.

Animals↗