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C L Dale

Publications and source records attributed to C L Dale.

3 recordsLinked to original sources
PubMed2001

Event-related brain potentials isolate the motor component in a tapping task.

Repetitive tapping is used to investigate temporal perception, memory, and reproduction. Intertap intervals and their variability, arise from cognitive and motor processes during the task. We used a measure of readiness potential onset to determine motor component latency during the timed interval. Subjects performed a paced, two-handed tapping task at four target intervals (1.5-2.75 s). Overall latency of production increased with increasing ISI, as did variability across target interval, conforming to a generalized Weber's law. In contrast, average motor latency was roughly 0.5 s across ISI. This constant motor latency may also indicate constant variability attributable to motor processing.

Acoustic Stimulation↗
PubMed1997

Toward a neurobiology of temporal cognition: advances and challenges.

A rich tradition of normative psychophysics has identified two ubiquitous properties of interval timing: the scalar property, a strong form of Weber's law, and ratio comparison mechanisms. Finding the neural substrate of these properties is a major challenge for neurobiology. Recently, advances have been made in our understanding of the brain structures important for timing, especially the basal ganglia and the cerebellum. Surgical intervention or diseases of the cerebellum generally result in increased variability in temporal processing, whereas both clock and memory effects are seen for neurotransmitter interventions, lesions and diseases of the basal ganglia. We propose that cerebellar dysfunction may induce deregulation of tonic thalamic tuning, which disrupts gating of the mnemonic temporal information generated in the basal ganglia through striato-thalamo-cortical loops.

Animals↗